uses chemosensation to recognize a variety of odors, many of which are released by bacteria, the major food source of . Specific amphid sensory neurons are known to detect different odorants. Here we show that the AWC neuron detects the attractive odorant 1-butanol. Because few odorants that are specifically recognized by the AWC neuron have been identified, we hope that the identification of this additional odorant will facilitate studies of the role of the AWC neuron in odor detection and discrimination.
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http://dx.doi.org/10.17912/micropub.biology.001370 | DOI Listing |
MicroPubl Biol
January 2025
Department of Neuroscience, Pomona College, Claremont, California, United States of America.
uses chemosensation to recognize a variety of odors, many of which are released by bacteria, the major food source of . Specific amphid sensory neurons are known to detect different odorants. Here we show that the AWC neuron detects the attractive odorant 1-butanol.
View Article and Find Full Text PDFG3 (Bethesda)
January 2025
Department of Neurobiology, School of Biological Sciences, University of California San Diego, La Jolla, CA 92093.
The conserved MAP3K DLKs are widely known for their functions in synapse formation, axonal regeneration and degeneration, and neuronal survival, notably under traumatic injury and chronic disease conditions. In contrast, their roles in other neuronal compartments are much less explored. Through an unbiased forward genetic screening in C.
View Article and Find Full Text PDFGlia
January 2025
State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science and Department of Neurosurgery, Zhongshan Hospital, Fudan University, Shanghai, P. R. China.
Astrocytes are the most abundant type of macroglia in the brain and play crucial roles in regulating neural development and functions. The diverse functions of astrocytes are largely determined by their morphology, which is regulated by genetic and environmental factors. However, whether and how the astrocyte morphology is affected by temperature remains largely unknown.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
January 2025
Group of Microbial Motility, Department of Biological Science, Division of Natural Science, Graduate School of Science, Nagoya University, Nagoya 464-8602, Japan.
Age-dependent sensory impairment, memory loss, and cognitive decline are generally attributed to neuron loss, synaptic dysfunction, and decreased neuronal activities over time. Concurrently, increased neuronal activity is reported in humans and other organisms during aging. However, it is unclear whether neuronal hyperactivity is the cause of cognitive impairment or a compensatory mechanism of circuit dysfunction.
View Article and Find Full Text PDFCell Genom
December 2024
Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA; Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA. Electronic address:
Gene expression in individual neurons can change during development to adulthood and can have large effects on behavior. Additionally, the insulin/insulin-like signaling (IIS) pathway regulates many of the adult functions of Caenorhabditis elegans, including learning and memory, via transcriptional changes. We used the deep resolution of single-nucleus RNA sequencing to define the adult transcriptome of each neuron in wild-type and daf-2 mutants, revealing expression differences between L4 larval and adult neurons in chemoreceptors, synaptic genes, and learning/memory genes.
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