Background: Frailty poses unique challenges for patients undergoing major cancer surgeries due to their extreme vulnerability to physiological stressors and can be an important factor in determining postoperative outcomes.
Aims And Objective: The objective of the study was to determine the incidence of frailty in patients undergoing major abdominal cancer surgeries and identify the risk factors predicting poor outcomes.
Materials And Methods: This was a prospective observational study conducted following institutional ethics approval and CTRI registration. We included 308 adult patients who underwent major abdominal cancer surgeries over two years. The preoperative frailty score was calculated using the 11-point modified frailty index score (mFI scale). Patients with a mFI score ≥ 3 points were considered frail. Clinical outcomes such as postoperative complications (Clavien-Dindo grades III and IV), surgical site infections, need for vasopressors, mechanical ventilation, acute kidney injury (AKI), length of ICU and hospital stay, and mortality at 30 days were recorded.
Results: The overall incidence of frailty according to the mFI scale was 8.1%. Age and higher American Society of Anesthesiology (ASA) status were significantly associated with frailty (OR -1.073, < 0.001, and OR -10.220, < 0.001) respectively. Frailty was an independent predictor of major postoperative complications (OR -8.147, 95%; CI -2.524-26.292, < 0.001). Frailty was also significantly associated with an increased duration of mechanical ventilation and length of stay ( < 0.001).
Conclusion: The modified frailty index (mFI) score remains a strong predictor of postoperative complications in patients undergoing major abdominal cancer surgeries and can help optimize risk factors to minimize complications.
How To Cite This Article: Joshi M, Bhoslae SJ, Pandhare J, Rathod R, Solanki SL, Kulkarni AP. Effect of Frailty on Postoperative Outcomes Following Major Abdominal Surgeries: A Prospective Observational Study. Indian J Crit Care Med 2024;28(11):1038-1043.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11773578 | PMC |
| http://dx.doi.org/10.5005/jp-journals-10071-24839 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Effect of Frailty on Postoperative Outcomes Following Major Abdominal Surgeries: A Prospective Observational Study.
Indian J Crit Care Med
November 2024
Department of Anaesthesiology, Critical Care and Pain, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, Maharashtra, India.
Background: Frailty poses unique challenges for patients undergoing major cancer surgeries due to their extreme vulnerability to physiological stressors and can be an important factor in determining postoperative outcomes.
Aims And Objective: The objective of the study was to determine the incidence of frailty in patients undergoing major abdominal cancer surgeries and identify the risk factors predicting poor outcomes.
Materials And Methods: This was a prospective observational study conducted following institutional ethics approval and CTRI registration.
Cocoa Seeds as a Phytobezoar Causing Intestinal Obstruction in a Ghanaian Child: A Case Report.
Cureus
December 2024
Emergency Medicine Department, Komfo Anokye Teaching Hospital, Kumasi, GHA.
Phytobezoars are indigestible organic matter that forms organized masses in the gastrointestinal tract. Seeds reported causing bezoars include sunflower seeds, watermelon seeds, and wild banana seeds. Cocoa seeds causing bezoar have not been reported.
View Article and Find Full Text PDFAntibiotic duration for common bacterial infections-a systematic review.
JAC Antimicrob Resist
February 2025
Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Background: Reducing antibiotic duration is a key stewardship intervention to mitigate antimicrobial resistance (AMR). We examined current evidence informing antibiotic duration for common bacterial infections to identify any gaps in terms of settings, patient populations and infectious conditions. Trial methodologies were assessed to identify areas for improvement.
View Article and Find Full Text PDFTHE IMPACT OF NEUTROPHIL-TO-LYMPHOCYTE RATIO ON SHORT- AND LONG-TERM PROGNOSIS FOLLOWING ELECTIVE INFRARENAL EVAR.
Ann Vasc Surg
January 2025
Hospital de Santa Marta, Unidade Local de Saúde São José, Lisboa, Portugal.
Objective: Neutrophil-to-lymphocyte ratio (NLR) is a readily available parameter, associated with long-term outcomes in cardiovascular conditions. This study aims to analyze the predictors of NLR and its impact on prognosis and disease-specific outcomes following EVAR.
Methods: Single-center retrospective cohort study.
Severe postoperative pancreatitis following treatment of peritoneal metastases.
Eur J Surg Oncol
January 2025
Program in Peritoneal Surface Malignancy, Washington Cancer Institute, Washington, DC, USA. Electronic address:
Postoperative pancreatitis is an unusual complication of upper abdominal surgery that can result in severe morbidity and has been associated with postoperative death. It can be caused by trauma to the surface of the gland, injury to pancreatic ducts, vascular compromise, ductal obstruction within the pancreas parenchyma or because of duodenal stagnation. Our database of peritoneal surface malignancy patients was surveyed in a search for patients who manifested signs and symptoms of severe postoperative pancreatitis.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!