Biomimetics as the transdisciplinary field leveraging biologically inspired solutions for technical and practical challenges has gained traction in recent decades. Despite its potential for innovation, the complexity of its process requires a deeper understanding of underlying tasks, leading to the development of various tools to aid this process. This study identified an inventory of 104 tools used in biomimetics, of which 24 have been classified as fully accessible, functional, and ready-to-use biomimetic tools. Additionally, it provides definitions and evaluation criteria for biomimetic tools, offering a structured approach to tool assessment. The 24 tools have been assessed based on ten criteria in a qualitative and quantitative analysis yielding an overview of their typology, accessibility, stage of development, and other key characteristics. Patterns of the typology development of tools over time revealed a trend towards integrating computational methods and artificial intelligence, thereby enhancing the tool's functionality and user engagement. However, gaps in tool functionality and maturity, such as the lack of tools designed to support technical processes, the absence of tools tailored for solution-based approaches, and insufficient evidence of successful tool application, highlight areas for future research. The study results underscore the need for empirical validation of tools and research into the effectiveness of holistic tools covering multiple stages of the biomimetic process. By addressing these gaps and leveraging existing strengths, the field of biomimetics can continue to advance, providing innovative solutions inspired by biological models.
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http://dx.doi.org/10.1088/1748-3190/adaff6 | DOI Listing |
Bioinspir Biomim
January 2025
Working Group Biomimetics, Faculty of Applied Informatics, Technology Campus Freyung, Deggendorf Institute of Technology, Grafenauer Str. 22, Freyung, Bayern, 94078, GERMANY.
Biomimetics as the transdisciplinary field leveraging biologically inspired solutions for technical and practical challenges has gained traction in recent decades. Despite its potential for innovation, the complexity of its process requires a deeper understanding of underlying tasks, leading to the development of various tools to aid this process. This study identified an inventory of 104 tools used in biomimetics, of which 24 have been classified as fully accessible, functional, and ready-to-use biomimetic tools.
View Article and Find Full Text PDFChem Sci
January 2025
School of Biomedical Engineering, Shanghai Jiao Tong University Shanghai 200240 China
Intracellular viscosity is a critical microenvironmental factor in various biological systems, and its abnormal increase is closely linked to the progression of many diseases. Therefore, precisely controlling the release of bioactive molecules in high-viscosity regions is vital for understanding disease mechanisms and advancing their diagnosis and treatment. However, viscosity alone cannot directly trigger chemical reactions.
View Article and Find Full Text PDFIn Vitro Model
June 2024
3B's Research Group, European Institute of Excellence in Tissue Engineering and Regenerative Medicine Headquarters, Parque de Ciência e Tecnologia, I3Bs - Research Institute on Biomaterials, Biodegradable and Biomimetics - University of Minho, Zona Industrial da Gandra - Avepark, Barco, Guimaraes, 4805-017 Portugal.
Soft microfluidic systems play a pivotal role in personalized medicine, particularly in in vitro diagnostics tools and disease modeling. These systems offer unprecedented precision and versatility, enabling the creation of intricate three-dimensional (3D) tissue models that can closely emulate both physiological and pathophysiological conditions. By leveraging innovative biomaterials and bioinks, soft microfluidic systems can circumvent the current limitations involving the use of polydimethylsiloxane (PDMS), thus facilitating the development of customizable systems capable of sustaining the functions of encapsulated cells and mimicking complex biological microenvironments.
View Article and Find Full Text PDFSmall
January 2025
School of Biomedical Sciences, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Fluorescent light-up aptamer/fluorogen pairs are powerful tools for tracking RNA in the cell, however limitations in thermostability and fluorescence intensity exist. Current in vitro selection techniques struggle to mimic complex intracellular environments, limiting in vivo biomolecule functionality. Taking inspiration from microenvironment-dependent RNA folding observed in cells and organelle-mimicking droplets, an efficient system is created that uses microscale heated water droplets to simulate intracellular conditions, effectively replicating the intracellular RNA folding landscape.
View Article and Find Full Text PDFNanomaterials (Basel)
January 2025
Innovative Laser Processing Group, Research Institute for Advanced Electronics and Photonics, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba 305-8568, Ibaraki, Japan.
Microfluidic sensors incorporated onto chips allow sensor miniaturization and high-throughput analyses for point-of-care or non-clinical analytical tools. Three-dimensional (3D) printing based on femtosecond laser direct writing (fs-LDW) is useful for creating 3D microstructures with high spatial resolution because the structures are printed in 3D space along a designated laser light path. High-performance biochips can be fabricated using the 'ship-in-a-bottle' integration technique, in which functional microcomponents or biomimetic structures are embedded inside closed microchannels using fs-LDW.
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