Atherosclerotic cardiovascular disease (ASCVD) remains the leading cause of morbidity and mortality worldwide. This review explores the evolving evidence base surrounding ASCVD prevention, particularly regarding nontraditional biomarkers, risk scores, and cardiovascular imaging modalities. Additionally, this review examines cardiovascular risk scores, including the PREVENT and MESA-CHD scores, which incorporate both traditional and nontraditional factors, thereby aspiring to offer a more equitable and precise risk assessment. Advances in cardiovascular imaging techniques, such as coronary artery calcium scoring and cardiac magnetic resonance imaging, are also discussed for their utility and potential. By integrating these advanced markers and imaging modalities, primary care clinicians can better identify and manage patients at risk, ultimately improving outcomes and reducing the burden of cardiovascular disease.
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