This paper presents a new strategy for the construction of the chiral 4-chromene skeleton. A series of chiral 2-trifluoromethyl-4-(indol-3-yl)-4-chromenes were synthesized in moderate to good yields (60-92%) with excellent enantioselectivity (up to 97% ee) through the palladium-catalyzed asymmetric condensation of 2-chromenes and indoles. These trifluoromethylated, stereochemically rich building blocks hold potential value in medicinal chemistry.
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Pd-Catalyzed Asymmetric Synthesis of Chiral 2-Trifluoromethyl-4-(indol-3-yl)-4-chromene Derivatives.
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