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EZH2 inhibition induces pyroptosis via RHA-mediated S100A9 overexpression in myelodysplastic syndromes.
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Department of Hematology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Myelodysplastic Syndromes (MDS) represent a group of heterogeneous myeloid clonal diseases derived from aberrant hematopoietic stem/progenitor cells. Enhancer of zeste homolog 2 (EZH2) is an important regulator in gene expression through methyltransferase-dependent or methyltransferase-independent mechanisms. Herein, we found EZH2 inhibition led to MDS cell pyroptosis through RNA Helicase A (RHA) down-regulation induced overexpression of S100A9, a key regulator of inflammasome activation and pyroptosis.
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Department of Psychiatry, University of Oxford, Warneford Hospital, Warneford Lane, Oxford, OX3 7JX, United Kingdom; Oxford Health NHS Foundation Trust, Warneford Hospital, Warneford Lane, Oxford, OX3 7JX, United Kingdom; Oxford Precision Psychiatry Lab, NIHR Oxford Health Biomedical Research Centre, Oxford, OX3 7JX, United Kingdom.
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We introduce and explore the notion of texture of an arbitrary quantum state, in a selected basis. In the first part of this Letter we develop a resource theory and show that state texture is adequately described by an easily computable monotone, which is also directly measurable. It is shown that textures are useful in the characterization of unknown quantum gates in universal circuit layers.
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