Antifungal activity of 2-adamantylamine hydrochloride on and .

Increased virulence and drug resistance in species of resulted in reduced disease control and further demand the development of potent antifungal drugs. The repurposing of non-antifungal drugs and combination therapy has become an attractive alternative to counter the emerging drug resistance and toxicity of existing antifungal drugs against and non-albicans species. This study aimed to accelerate antifungal drug development process by drug repurposing approach. In this study, the antifungal effects of the antiviral drug, 2-adamantylamine hydrochloride (2-AM), were explored against and . Broth microdilution measured efficacy of 2-AM, whereas reactive oxygen species (ROS) accumulation and ergosterol quantification, cell cycle and phosphatidylserine externalization studies were detailed to investigate the antifungal mode of 2-AM action. Results showed that 2-AM had fungicidal action against both the strains where, 2-AM further inhibited morphogenic transitions as well. Antibiofilm action of 2-AM on was evidenced on urinary catheters. G2/M phase arrest and apoptosis indicated ROS induced antifungal effect of 2-AM on both strains. Results of studies offers insight into the antifungal activity of 2-AM and may serve as an effective antifungal repurposed candidate against and .