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School of Integrative Engineering, Chung-Ang University, Seoul, Republic of Korea.
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Institute for Translational Medicine, The Affiliated Hospital of Qingdao University, College of Medicine, Qingdao University, 38 Dengzhou Road, Qingdao, 266021, China.
Clinically, multimodal therapies are adopted worldwide for the management of cancer, which continues to be a leading cause of death. In recent years, immunotherapy has firmly established itself as a new paradigm in cancer care that activates the body's immune defense to cope with cancer. Immunotherapy has resulted in significant breakthroughs in the treatment of stubborn tumors, dramatically improving the clinical outcome of cancer patients.
View Article and Find Full Text PDFApproved natural products-derived nanomedicines for disease treatment.
Chin J Nat Med
December 2024
School of Science, China Pharmaceutical University, Nanjing 2111198, China. Electronic address:
In recent years, there has been an increasing emphasis on exploring innovative drug delivery approaches due to the limitations of conventional therapeutic strategies, such as inadequate drug targeting, insufficient therapeutic efficacy, and significant adverse effects. Nanomedicines have emerged as a promising solution with notable advantages, including extended drug circulation, targeted delivery, and improved bioavailability, potentially enhancing the clinical treatment of various diseases. Natural products/materials-derived nanomedicines, characterized by their natural therapeutic efficacy, superior biocompatibility, and safety profile, play a crucial role in nanomedicine-based treatments.
View Article and Find Full Text PDFROS Regulation in CNS Disorder Therapy: Unveiling the Dual Roles of Nanomedicine.
Small
December 2024
School of Life Science, Beijing Institute of Technology, Beijing, 100081, P. R. China.
The treatment of brain diseases has always been the focus of attention. Due to the presence of the blood-brain barrier (BBB), most small molecule drugs are difficult to reach the brain, leading to undesirable therapeutic outcomes. Recently, nanomedicines that can cross the BBB and precisely target lesion sites have emerged as thrilling tools to enhance the early diagnosis and treat various intractable brain disorders.
View Article and Find Full Text PDFArticle Synopsis
- Cancer rates are rising globally, necessitating more effective and low-toxicity treatment options, which can be achieved through nanotechnology tailored to individual patients' tumors.
- Nanomedicine is making strides with various nanoformulations in clinical trials and some already on the market, but there are hurdles to widespread use, including ethical, safety, and cost concerns.
- The text highlights advances in personalized diagnostics and therapies through technologies like organ-on-chip and CRISPR/Cas9, while also addressing the future prospects and challenges of integrating nano-based precision oncology into everyday clinical practice.
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