Arechuines A-D, arecoline alkaloids from the peels of L.

Four novel arecoline alkaloid atropisomers, arechuines A-D (-), were obtained from the peels of L. Their structures were elucidated by UV, IR, MS and NMR spectra. The absolute configurations of (+)/(-)- were determined by comparing the experimental and calculated ECD spectra. Compounds - were evaluated for their neuroprotective effects in glutamate-induced HT22 cell and revealed potent neuroprotective effects at 10 μM. These are the first reported arecoline alkaloid atropisomers isolated from