Objectives: To classify under 5-y-old children into normal, short, severe short and tall categories as per WHO (2006) and Indian 2019 synthetic growth charts and to compare the change in the proportion of stunted children based on these two charts.
Methods: This study was done on 1557 (795 boys) apparently healthy children of age group 0-5 y who attended outpatient clinics for routine vaccination and their stature categories were compared on WHO 2006 vs. 2019 Indian synthetic charts. Children were categorized into severe short, short, normal and tall on both charts by calculating z scores.
Results: On WHO charts 73.5% children were classified as normal vs. 85.4% on 2019 Indian synthetic charts. The mean Z score for height for age as per WHO was -0.85 (+/-1.62), whereas as for 2019 synthetic charts was -0.37 (+/-1.38). While using WHO growth charts the prevalence of short stature was 15.03%, and severe short stature was 7.51%, which dropped to 7.77% for short stature and 2.38% for severe short stature on 2019 synthetic charts, respectively.
Conclusions: WHO Growth charts overdiagnose short stature by 12.4% (WHO 22.54% vs. Indian synthetic 10.15%) in an apparently normal population of under five children. Use of regional growth charts may reduce the need to unnecessarily investigate normal children.
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http://dx.doi.org/10.1007/s12098-025-05437-6 | DOI Listing |
JBMR Plus
February 2025
Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki 00014, Finland.
Hypophosphatemic rickets is a rare bone disease characterized by short stature, bone deformities, impaired bone mineralization, and dental problems. Most commonly, hypophosphatemic rickets is caused by pathogenic variants in the X-chromosomal gene, but autosomal dominant and recessive forms also exist. We investigated a Finnish family in which the son (index, 29 yr) and mother (56 yr) had hypophosphatemia since childhood.
View Article and Find Full Text PDFIndian J Pediatr
January 2025
Department of Pediatrics, Bharati Vidyapeeth Medical College and Hospital, Dhankawadi, Pune, 411043, India.
Objectives: To classify under 5-y-old children into normal, short, severe short and tall categories as per WHO (2006) and Indian 2019 synthetic growth charts and to compare the change in the proportion of stunted children based on these two charts.
Methods: This study was done on 1557 (795 boys) apparently healthy children of age group 0-5 y who attended outpatient clinics for routine vaccination and their stature categories were compared on WHO 2006 vs. 2019 Indian synthetic charts.
Sci Rep
January 2025
Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Age at menarche may be associated with cardiovascular disease risk factors in different ethnic groups. The purpose of this study was to identify the association of cardiovascular disease (CVD) risk factors with age at menarche (AAM) in Mashhad, the second biggest city in Iran. This was a cross- sectional study based on cohort data of 2353 women (35-65 years) from Mashhad, Iran for whom the age at menarche was reported.
View Article and Find Full Text PDFBMJ Case Rep
January 2025
Endocrinology Department, Sri Ramachandra Institute of Higher Education and Research, Chennai, India
TSHB gene mutation results in isolated central congenital hypothyroidism (iCCH). Often diagnosed late, mild neurocognitive impairment is common despite thyroxine initiation. We discuss a female term neonatal presenting with prolonged unconjugated hyperbilirubinaemia.
View Article and Find Full Text PDFEndocrinol Diabetes Metab Case Rep
January 2025
Summary: Short stature is a common complaint among pediatric visits and the differential diagnosis is extensive. Although some variations in growth are normal, deviation from normal growth is often the first symptom of chronic disease in children. This is true for hormone abnormalities including growth hormone deficiency, hypothyroidism and glucocorticoid excess.
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