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EMERALD in the making? A promising blood-based microRNA panel to detect oesophageal adenocarcinoma and Barrett's oesophagus.
Gut
January 2025
Gastroenterology and Hepatology, Mayo Clinic, Scottsdale, Arizona, USA
Student-Led Falls Prevention Program for Community-Dwelling Older Adults in a Rural Community: A Pilot Study.
Aust J Rural Health
February 2025
Central Queensland Centre for Rural and Remote Health, James Cook University Emerald, Queensland, Australia.
Introduction: A third of community-dwelling adults over the age of 65 years fall each year, making falls a significant concern for the elderly. Older people living in community-dwellings account for 73% of fall-related hospitalisations in older populations. Little is known about identifying, reaching at-risk people, and delivering these interventions in rural communities.
View Article and Find Full Text PDFEffectiveness of tofacitinib versus tumor necrosis factor inhibitors and in those receiving tofacitinib as different lines of therapy in patients with rheumatoid arthritis: results from the United States CorEvitas Rheumatoid Arthritis Registry.
Clin Rheumatol
February 2025
Pfizer Inc, Collegeville, PA, USA.
Objectives: To compare effectiveness of tofacitinib versus tumor necrosis factor inhibitors (TNFi), and across tofacitinib lines of therapy, in patients with rheumatoid arthritis (RA), using US CorEvitas RA Registry data.
Methods: Analysis included patients with RA initiating tofacitinib or TNFi with a 12-month follow-up visit between November 2012-February 2021. Primary (Clinical Disease Activity Index-defined low disease activity [CDAI-LDA: CDAI ≤ 10]) and secondary (clinical/disease activity/patient-reported) effectiveness outcomes were assessed at month 12.
Dual role of neuroplastin in pancreatic β cells: Regulating insulin secretion and promoting islet inflammation.
Proc Natl Acad Sci U S A
August 2024
Department of Medicine, Division of Endocrinology, Metabolism, and Lipid Research, Washington University School of Medicine, St. Louis, MO 63110.
Mesencephalic astrocyte-derived neurotrophic factor (MANF) is an endoplasmic reticulum (ER)-resident secretory protein that reduces inflammation and promotes proliferation in pancreatic β cells. Numerous studies have highlighted the potential of MANF as a therapeutic agent for diabetes mellitus (DM), making it essential to understand the mechanisms underlying MANF's functions. In our previous search for a molecule that mediates MANF signaling, we identified Neuroplastin (NPTN) as a binding partner of MANF that localizes on the cell surface.
View Article and Find Full Text PDFStrengthening Mental Health Though Resilience in Nursing Students: A Protocol for a Comprehensive Scoping Review.
Nurs Rep
November 2024
Center for Studies and Development of Health Education, Faculty of Medicine of São José do Rio Preto (CEDES/FAMERP), São José do Rio Preto 15090-000, Brazil.
Background: Nursing students face unique challenges during their university education, making them vulnerable to mental health problems. Psychological resilience has been identified as a protective factor against these issues. However, previous reviews have identified gaps in the literature on resilience and mental health among nursing students.
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