Coats-like response refers to a condition where abnormal telangiectatic retinal vessels and aneurysms associated with subretinal exudation are seen in the setting of other ocular or systemic diseases. So far, it has been described with various ocular disorders like retinitis pigmentosa, chronic ischemic branch retinal vein obstruction and pars planitis. A man in his 30s presented with a 1-month history of diminution of vision in the left eye. On examination, the left eye fundus showed extensive subretinal exudation along with evidence of old and recent periphlebitis. Fluorescein angiography revealed multiple telangiectatic vessels and peripheral aneurysms along with perivenular leak. Optical coherence tomography of the macula demonstrated cystoid oedema with subretinal fluid. The case was diagnosed as Coats-like response with occlusive periphlebitis and was successfully managed with oral steroids alone.
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http://dx.doi.org/10.1136/bcr-2024-263232 | DOI Listing |
BMJ Case Rep
January 2025
Ophthalmology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India.
Coats-like response refers to a condition where abnormal telangiectatic retinal vessels and aneurysms associated with subretinal exudation are seen in the setting of other ocular or systemic diseases. So far, it has been described with various ocular disorders like retinitis pigmentosa, chronic ischemic branch retinal vein obstruction and pars planitis. A man in his 30s presented with a 1-month history of diminution of vision in the left eye.
View Article and Find Full Text PDFBMC Ophthalmol
January 2025
Dept. of Retina and Vitreous, Narayana Nethralaya, #121/C, 1st R Block, Chord Road, Rajaji Nagar, Bengaluru, 560010, India.
Purpose: To report a rare case of a Coats-like response developing after vitreoretinal surgery for proliferative diabetic retinopathy (PDR) and its successful management with retinal laser photocoagulation and adjunctive intravitreal steroids.
Case Description: A 52-year-old woman with a five-year history of type 2 diabetes mellitus and hypertension presented with decreased vision in the left eye (counting fingers at 1 m). Examination revealed high-risk PDR in both eyes, with a subtotal macula-off combined retinal detachment in the left eye.
J Vitreoretin Dis
November 2024
Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA.
To report a unique case of retinal exudation consistent with a Coats-like response and associated with mutations in , confirming the diagnosis of Poretti-Boltshauser syndrome. A case and its findings were analyzed. A 24-year-old woman presented with mild peripheral avascularity, circumferential membranes at the edge of the vascularized retina, exudation, numerous vessels with aneurysmal changes, and inferior retinal elevation in both eyes.
View Article and Find Full Text PDFOphthalmology
December 2023
Moorfields Eye Hospital, London, United Kingdom; UCL Institute of Ophthalmology, University College London, London, United Kingdom. Electronic address:
PLoS Genet
June 2022
The Jackson Laboratory, Bar Harbor, Maine, United States of America.
Mutations in the apicobasal polarity gene CRB1 lead to diverse retinal diseases, such as Leber congenital amaurosis, cone-rod dystrophy, retinitis pigmentosa (with and without Coats-like vasculopathy), foveal retinoschisis, macular dystrophy, and pigmented paravenous chorioretinal atrophy. Limited correlation between disease phenotypes and CRB1 alleles, and evidence that patients sharing the same alleles often present with different disease features, suggest that genetic modifiers contribute to clinical variation. Similarly, the retinal phenotype of mice bearing the Crb1 retinal degeneration 8 (rd8) allele varies with genetic background.
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