Left atrial appendage velocity, association with inflammatory indices in non-valvular atrial fibrillation patients.

Introduction: Decreased left atrial appendage emptying velocity (LAAV) is a marker for thrombus formation. This study evaluates the association between LAAV and inflammatory indices in non-valvular atrial fibrillation (AF) patients.

Methods: The study population was 1428 patients with AF, 875 of whom enrolled. Based on the LAAV, patients were divided into three groups of 262 patients with a velocity of <25 cm/s, 360 patients with a velocity of 25 to 55 cm/s, and 253 patients with a velocity of >55 cm/s to assess and compare in terms of inflammatory indices, including the platelet-to-lymphocyte ratio, neutrophil-to-lymphocyte ratio, systemic immune inflammation index, neutrophil - to - platelet ratio and white blood cell-to-platelet ratio (WPR).

Results: There was no statistical difference in the level of inflammatory indices between the three groups, and none of them were related to LAAV ( > .05) except WPR with a weak negative correlation ( = 0.01,  = -0.10). Patients with lower LAAV were found to have a higher age ( = 0.001), decreased left ventricular ejection fraction ( = 0.001) and greater left atrial volume index ( = 0.001).

Conclusion: This study did not show any association between inflammatory indices and LAAV in non-valvular AF patients except for the WPR.