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Dying for change: A roadmap to refine the fish acute toxicity test after 40 years of applying a lethal endpoint.
Ecotoxicol Environ Saf
October 2021
Department of Toxicology, Centre for Radiation, Chemical and Environmental, Hazards Public Health England, Chilton, Oxfordshire OX11 0RQ, UK.
The fish acute toxicity test (TG203; OECD, 2019) is frequently used and highly embedded in hazard and risk assessment globally. The test estimates the concentration of a chemical that kills 50% of the fish (LC) over a 96 h exposure and is considered one of the most severe scientific procedures undertaken. Over the years, discussions at the Organisation for Economic Co-operation and Development (OECD) have resulted in changes to the test which reduce the number of fish used, as well as the development of a (potential) replacement test (TG236, OECD, 2013).
View Article and Find Full Text PDFThe 2020 Five Domains Model: Including Human-Animal Interactions in Assessments of Animal Welfare.
Animals (Basel)
October 2020
Saddletops Pty Ltd., P.O. Box 557, Gatton, QLD 4343, Australia.
Throughout its 25-year history, the Five Domains Model for animal welfare assessment has been regularly updated to include at each stage the latest authenticated developments in animal welfare science thinking. The domains of the most up-to-date Model described here are: 1 Nutrition, 2 Physical Environment, 3 Health, 4 Behavioural Interactions and 5 Mental State. The first four domains focus attention on factors that give rise to specific negative or positive subjective experiences (affects), which contribute to the animal's mental state, as evaluated in Domain 5.
View Article and Find Full Text PDFImplementing guidelines on reporting research using animals (ARRIVE etc.): new requirements for publication in BJP.
Br J Pharmacol
July 2015
Research Animals Department, Science Group, RSPCA, West Sussex, UK.
The ARRIVE guidelines have been implemented in BJP for 4 years with the aim of increasing transparency in reporting experiments involving animals. BJP has assessed our success in implementing them and concluded that we could do better. This editorial discusses the issues and explains how we are changing our requirements for authors to report their findings in experiments involving animals.
View Article and Find Full Text PDFReport of the 2006 RSPCA/UFAW Rodent Welfare Group meeting.
Lab Anim (NY)
May 2008
Research Animals Department, Science Group, RSPCA, Wilberforce Way, Southwater, West Sussex RH13 9RS, UK.
The RSPCA/UFAW Rodent Welfare Group holds a one-day meeting every autumn to discuss current welfare research and to exchange views on rodent welfare issues. A key aim of the group is to encourage people to think about the lifetime experience of laboratory rodents, ensuring that every potential influence on their well-being has been reviewed and refined. Speakers at the 2006 meeting presented preliminary findings of ongoing studies and discussed regulatory updates.
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