Background/purpose: The extract of the soft coral has shown an anti-cancer activity in various cancer cells. However, its effect on the oral squamous cell carcinoma cell (OSCC) lines remains unclear. The purpose of this study is to investigate the anti-cancer effects of the extract of (C127) on the OSCC cells.
Materials And Methods: This study evaluated the effects of the soft coral extract of (C127) on SAS and Ca9-22 cells, cell viability, migration ability, and apoptosis. Electric cell-substrate impedance sensing (ECIS) was parallelly used on SAS cells to confirm the results.
Results: C127 affected cell viability, morphology, and migration ability in both cell lines. In SAS cells, C127 inhibited cell viability in a dose dependent manner ( < 0.001) and induced apoptosis at 10 μg/mL ( < 0.05). In addition, C127 significantly inhibited migration ability on both cell lines in a dose-dependent manner ( < 0.001).
Conclusion: This study illustrated the potential of marine-derived compounds of on its activity against OSCC cells.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11763181 | PMC |
| http://dx.doi.org/10.1016/j.jds.2024.06.016 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Humic substances modulate bacterial communities and mitigate adverse effects of temperature stress in coral reef organisms.
J Appl Microbiol
January 2025
Centre for Environmental and Marine Studies (CESAM) and Department of Biology, University of Aveiro, Aveiro, Portugal.
Aims: In the present study, we tested if terrestrially-derived humic substances (HS) could mitigate the adverse effects of elevated temperature and UVB radiation on the bacterial communities of two hard corals (Montipora digitata and Montipora capricornis), one soft coral (Sarcophyton glaucum), sediment and water. We also examined the impact of temperature, UVB radiation and HS supplementation on coral photosynthetic activity, a proxy for coral bleaching.
Methods And Results: We performed a multifactorial experiment using a randomized-controlled microcosm setup.
Soft coral Lobophytum crassum extract inhibits migration and induces apoptosis capabilities in human oral squamous cell carcinoma cells.
J Dent Sci
January 2025
Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan.
Background/purpose: The extract of the soft coral has shown an anti-cancer activity in various cancer cells. However, its effect on the oral squamous cell carcinoma cell (OSCC) lines remains unclear. The purpose of this study is to investigate the anti-cancer effects of the extract of (C127) on the OSCC cells.
View Article and Find Full Text PDFNeonatal Abandonment and Hydrocephalus in Antillean Manatees (): Is There a Causal Relationship?
Animals (Basel)
January 2025
Animal Pathology Laboratory (LAPATO), Institute of Veterinary Medicine (IMV), Federal University of Pará (UFPA), Castanhal 68745-000, PA, Brazil.
Manatees are semi-social animals, with the mother-calf relationship being considered long-lasting for the species. However, some events lead to the separation of this pair. Orphaned manatee calves can be adopted by other females of the same species.
View Article and Find Full Text PDFAnthoteibinenes F-Q: New Sesquiterpenes from the Irish Deep-Sea Coral .
Mar Drugs
January 2025
Department of Chemistry, University of South Florida, 4202 E. Fowler Avenue, CHE205, Tampa, FL 33620, USA.
New technology has opened opportunities for research and exploration of deep-water ecosystems, highlighting deep-sea coral reefs as a rich source of novel bioactive natural products. During our ongoing investigation of the chemodiversity of the Irish deep sea and the soft coral we report 12 unreported cadinene-like functionalized sesquiterpenes, anthoteibinenes F-Q. The metabolites were isolated using both bioassay- and H NMR-guided approaches.
View Article and Find Full Text PDFFatty Acids in Cnidaria: Distribution and Specific Functions.
Mar Drugs
January 2025
A.V. Zhirmunsky National Scientific Center of Marine Biology, Far Eastern Branch, Russian Academy of Sciences, ul. Palchevskogo 17, Vladivostok 690041, Russia.
The phylum Cnidaria comprises five main classes-Hydrozoa, Scyphozoa, Hexacorallia, Octocorallia and Cubozoa-that include such widely distributed and well-known animals as hard and soft corals, sea anemones, sea pens, gorgonians, hydroids, and jellyfish. Cnidarians play a very important role in marine ecosystems. The composition of their fatty acids (FAs) depends on food (plankton and particulate organic matter), symbiotic photosynthetic dinoflagellates and bacteria, and de novo biosynthesis in host tissues.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!