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| http://dx.doi.org/10.1093/lifemedi/lnac041 | DOI Listing |
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Fine mapping of RNA isoform diversity using an innovative targeted long-read RNA sequencing protocol with novel dedicated bioinformatics pipeline.
BMC Genomics
September 2024
Laboratoire de biologie et de génétique du cancer, Département de Biopathologie, Centre François Baclesse, Caen, 14000, France.
Article Synopsis
- Solving mRNA transcript structures is challenging with traditional methods, but long-read sequencing addresses this by providing direct sequence information.
- A new targeted enrichment method was developed to capture transcripts of genes related to hereditary breast and ovarian cancer, leading to the identification of 1,231 unique transcripts in eight patients.
- The SOSTAR pipeline successfully annotated transcript structures and discovered key splicing events, including the identification of a retrotransposon related to unexplained inheritance cases.
PE6c greatly enhances prime editing in transgenic rice plants.
J Integr Plant Biol
September 2024
State Key Laboratory of Plant Environmental Resilience, College of Biological Sciences, China Agricultural University, Beijing, 100193, China.
Prime editing is a versatile CRISPR/Cas-based precise genome-editing technique for crop breeding. Four new types of prime editors (PEs) named PE6a-d were recently generated using evolved and engineered reverse transcriptase (RT) variants from three different sources. In this study, we tested the editing efficiencies of four PE6 variants and two additional PE6 constructs with double-RT modules in transgenic rice (Oryza sativa) plants.
View Article and Find Full Text PDFDiversity and evolution of transposable elements in the plant-parasitic nematodes.
BMC Genomics
May 2024
Forestry Vocational School, Düzce University, Konuralp Campus, 81620, Düzce, Türkiye.
Background: Transposable elements (TEs) are mobile DNA sequences that propagate within genomes, occupying a significant portion of eukaryotic genomes and serving as a source of genetic variation and innovation. TEs can impact genome dynamics through their repetitive nature and mobility. Nematodes are incredibly versatile organisms, capable of thriving in a wide range of environments.
View Article and Find Full Text PDFMobile genetic element-based gene editing and genome engineering: Recent advances and applications.
Biotechnol Adv
April 2024
Department of Bioengineering and Nano-Bioengineering, Incheon National University, 119 Academy-ro, Yeonsu-gu, Incheon 22012, Republic of Korea; Division of Bioengineering, College of Life Sciences and Bioengineering, Incheon National University, 119 Academy-ro, Yeonsu-gu, Incheon 22012, Republic of Korea; Research Center for Bio Materials & Process Development, Incheon National University, 119 Academy-ro, Yeonsu-gu, Incheon 22012, Republic of Korea. Electronic address:
Genome engineering has revolutionized several scientific fields, ranging from biochemistry and fundamental research to therapeutic uses and crop development. Diverse engineering toolkits have been developed and used to effectively modify the genome sequences of organisms. However, there is a lack of extensive reviews on genome engineering technologies based on mobile genetic elements (MGEs), which induce genetic diversity within host cells by changing their locations in the genome.
View Article and Find Full Text PDFEndogenous retrovirus HERVH-derived lncRNA controls human trophoblast development.
Proc Natl Acad Sci U S A
March 2024
Advanced Medical Technology Center, The First Affiliated Hospital, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China.
Article Synopsis
- Endogenous retroviruses (ERVs) in mammals can help control how cells in the placenta grow and develop.
- A specific type of ERV, called HERVH, plays an important role in the development of trophoblasts, which are key cells in the placenta.
- Research shows that something called LTR7C, derived from HERVH, can help grow placental stem cells but can also cause problems in certain pregnancy complications, like early-onset preeclampsia.
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