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CD157 selectively identifies hPSCs with enhanced hepatic differentiation capacity.
Life Med
August 2024
CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
CD157: From immunoregulatory protein to potential therapeutic target.
Immunol Lett
January 2019
Laboratory of Immunogenetics, Department of Medical Sciences, University of Torino, Via Santena 19, 10126 Torino, Italy. Electronic address:
CD157/BST1 glycosylphosphatidylinositol-anchored glycoprotein is an evolutionary conserved dual-function receptor and β-NAD+-metabolizing ectoenzyme of the ADP-ribosyl cyclases gene family. Identified as bone marrow stromal cell and myeloid cell differentiation antigen, CD157 turned out to have a wider expression than originally assumed. The functional significance of human CD157 as an enzyme remains unclear, while it was well established in mouse models.
View Article and Find Full Text PDFPlasma cell output from germinal centers is regulated by signals from Tfh and stromal cells.
J Exp Med
April 2018
Institute of Immunology and Immunotherapy, Medical School/IBR, University of Birmingham, Birmingham, England, UK
Article Synopsis
- Germinal centers (GCs) are crucial for B cell affinity maturation, but the regulation of their cellular output is not fully understood.
- Researchers identify that plasmablasts, which are important for antibody production, emerge at the interface of the GC and T zone (GTI) early in the GC response.
- Two key factors influencing this emergence are Tfh-derived IL-21, which promotes plasmablast production, and TNFSF13 (APRIL) from specific fibroblastic reticular cells, with blocking their receptor reducing plasmablast numbers, suggesting a role in immune responses.
High-sensitivity 5-, 6-, and 7-color PNH WBC assays for both Canto II and Navios platforms.
Cytometry B Clin Cytom
July 2018
Institute of Hematology and Blood Transfusion, Prague, Czech Republic.
Background: Paroxysmal Nocturnal Hemoglobinuria (PNH) is a rare acquired hematopoietic stem cell disorder characterized by an inability to make Glyco-Phosphatidyl-Inositol (GPI)-linked cell surface structures. Fluorescent proaerolysin (FLAER-Alexa488) is increasingly used to detect GPI-deficient WBCs by flow cytometry. However, FLAER is not available in all countries and is expensive to obtain in others.
View Article and Find Full Text PDFCombination of CD157 and FLAER to Detect Peripheral Blood Eosinophils by Multiparameter Flow Cytometry.
J Clin Exp Hematop
August 2016
Division of Hematology , Department of Clinical and Experimental Medicine, University of Pisa.
The identification of eosinophils by flow cytometry is difficult because most of the surface antigens expressed by eosinophils are shared with neutrophils. Some methods have been proposed, generally based on differential light scatter properties, enhanced autofluorescence, lack of CD16 or selective positivity of CD52. Such methods, however, show several limitations.
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