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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11749112 | PMC |
| http://dx.doi.org/10.1093/lifemedi/lnac007 | DOI Listing |
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Cancer cells are featured with uncontrollable activation of cell cycle, and microRNA deficiency drives tumorigenesis. The RNA-dependent RNA polymerase (RDR) is essential for small-RNA-mediated immune response in plants but is absent in vertebrates. Here, we show that ectopic expression of plant RDR1 can generally inhibit cancer cell proliferation.
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