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Psychiatric Assessment in Patients with Mild Temporal Lobe Epilepsy.
Behav Neurol
July 2019
Neurology Unit, Department of Medical and Surgical Sciences, University Magna Graecia, Catanzaro, Italy.
Objectives: The findings of previous studies focused on personality disorders in epileptic patients are difficult to interpret due to nonhomogeneous samples and noncomparable methods. Here, we aimed at studying the personality profile in patients with mild temporal lobe epilepsy (mTLE) with psychiatric comorbidity.
Materials And Methods: Thirty-five patients with mTLE (22 males, mean age 40.
Dilution correction for dynamically influenced urinary analyte data.
Anal Chim Acta
November 2018
Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, Germany; Institute of Epidemiology, Helmholtz Zentrum München, Germany; German Center for Diabetes Research (DZD), München, Germany.
Urinary analyte data has to be corrected for the sample specific dilution as the dilution varies intra- and interpersonally dramatically, leading to non-comparable concentration measures. Most methods of dilution correction utilized nowadays like probabilistic quotient normalization or total spectra normalization result in a division of the raw data by a dilution correction factor. Here, however, we show that the implicit assumption behind the application of division, log-linearity between the urinary flow rate and the raw urinary concentration, does not hold for analytes which are not in steady state in blood.
View Article and Find Full Text PDFValidation of soluble amyloid-β precursor protein assays as diagnostic CSF biomarkers for neurodegenerative diseases.
J Neurochem
April 2016
Neurochemistry Laboratory and Biobank, Department of Clinical Chemistry, VU University Medical Center, Amsterdam, The Netherlands.
Analytical validation of a biomarker assay is essential before implementation in clinical practice can occur. In this study, we analytically validated the performance of assays detecting soluble amyloid-β precursor protein (sAPP) α and β in CSF in two laboratories according to previously standard operating procedures serving this goal. sAPPα and sAPPβ ELISA assays from two vendors (IBL-international, Meso Scale Diagnostics) were validated.
View Article and Find Full Text PDFMemory and executive functions in patients with obsessive-compulsive disorder.
Cogn Behav Neurol
March 2014
*Clinic for OCD and Anxiety Disorders †Center for Psychiatric Research §Regional Center for Child and Adolescent Psychiatry, Aarhus University Hospital Risskov, Risskov, Denmark ‡Vejlefjord Rehabilitation, Stouby, Denmark.
Objective: We investigated whether patients with obsessive-compulsive disorder have poorer memory and executive functions than healthy controls.
Background: The relatively inconsistent previous findings on this question reflect a lack of well-matched control groups, the inclusion of patients with comorbidity, and the use of noncomparable neuropsychological tests to assess memory and executive functions.
Methods: We used well-accepted neuropsychological tests of memory and executive functions to assess 42 patients who had obsessive-compulsive disorder without comorbidity, and 42 healthy controls.
Drug use among prisoners: by any definition, it's a big problem.
Subst Use Misuse
July 2011
Police College of Finland, Research and Development, Tampere, Finland.
According to several studies, the prevalence of drug use (1) among prisoners is manyfold compared to general population. However, comparisons across studies are hampered by the use of a variety of mutually noncomparable methodologies. We report substance use among Finnish prisoners using three methods and analyze these differences.
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