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| http://dx.doi.org/10.1093/lifemedi/lnae037 | DOI Listing |
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Xenotransplantation: How close are we to clinical applications?
Life Med
October 2024
Beijing Key Laboratory of Preclinical Research and Evaluation for Cardiovascular Implant Materials, Animal Experimental Centre, National Centre for Cardiovascular Disease, Department of Cardiac Surgery, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.
A high-quality genome assembly of the Spectacled Fulvetta (Fulvetta ruficapilla) endemic to China.
Sci Data
November 2024
Key Laboratory of Genetic Evolution & Animal Models, State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650201, P. R. China.
The Spectacled Fulvetta (Fulvetta ruficapilla) is the type species of Fulvetta, an evolutionarily distinct group whose species show a high degree of sympatry in distribution and phenotypic convergence. To pave the way for insights into their adaptive evolution and speciation, we have assembled the first high quality reference genome for F. ruficapilla using high-fidelity (HiFi) long-read and Hi-C sequencing technologies.
View Article and Find Full Text PDFECG Features in Orthotopic Cardiac Xenotransplantation: Comparisons With Published Literature.
Xenotransplantation
November 2024
Division of Cardiac Surgery, Department of Surgery, Children's Hospital Los Angeles, Keck School of Medicine, Los Angeles, California, USA.
Introduction: Although there is a plethora of literature on electrocardiographic changes following cardiac allotransplantation, there is little in the field of cardiac xenotransplantation. The only published literature to date is that of the first pig-to-human cardiac xenotransplantation. Here we take a close look at the electrocardiographic parameters in four non-human primate recipients of orthotopic cardiac xenotransplantation to develop baseline metrics for comparison.
View Article and Find Full Text PDFProduction of second-generation sheep clones via somatic cell nuclear transfer using amniotic cells as nuclear donors.
Theriogenology
January 2025
College of Life Sciences, Inner Mongolia Agricultural University, Hohhot, 010018, China; College of Medicine, Hainan Vocational University of Science and Technology, Haikou, 571126, China; Inner Mongolia Key Laboratory of Biomanufacture, Hohhot, 010018, China. Electronic address:
Somatic Cell Nuclear Transfer (SCNT) has transformed animal genetic improvement, gene-editing in model production, xenotransplantation, and conservation efforts for endangered species. However, SCNT-derived embryos occasionally display developmental abnormalities, and following embryo transfer, the miscarriage rate is high. Gene-edited fetuses may experience birth defects, resulting in decreased survival rates.
View Article and Find Full Text PDFCharacterizing coagulation responses in humans and nonhuman primates following kidney xenotransplantation-A narrative review.
Am J Hematol
February 2025
Department of Biomedical and Molecular Sciences, School of Medicine, Queen's University, Kingston, Ontario, Canada.
The recent report of the first pig kidney transplant in a living human brings hope to thousands of people with end-stage kidney failure. The scientific community views this early success with caution as kidney xenotransplantation exhibits many challenges and barriers. One of these is coagulation dysregulation.
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