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| http://dx.doi.org/10.1093/lifemedi/lnac039 | DOI Listing |
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Advances in mechanotransduction and sonobiology: effects of audible acoustic waves and low-vibration stimulations on mammalian cells.
Biophys Rev
December 2024
Department of Optics, Pharmacology and Anatomy, University of Alicante, San Vicente del Raspeig, Spain.
In recent decades, research on mechanotransduction has advanced considerably, focusing on the effects of audible acoustic waves (AAWs) and low-vibration stimulation (LVS), which has propelled the field of sonobiology forward. Taken together, the current evidence demonstrates the influence of these biosignals on key cellular processes, such as growth, differentiation and migration in mammalian cells, emphasizing the determining role of specific physical parameters during stimulation, such as frequency, sound pressure level/amplitude and exposure time. These mechanical waves interact with various cellular elements, including ion channels, primary cilia, cell-cell adhesion receptors, cell-matrix and extracellular matrix proteins, and focal adhesion complexes.
View Article and Find Full Text PDFCancer-associated fibroblasts induce almonertinib resistance in non-small cell lung cancer.
J Transl Med
January 2025
Department of Oncology, The Second Hospital of Nanjing, Affiliated to Nanjing University of Chinese Medicine, Nanjing, 210003, China.
Background: Almonertinib is the initial third-generation EGFR-TKI in China, but its resistance mechanism is unknown. Cancer-associated fibroblasts (CAFs) are essential matrix components in the tumor microenvironment, but their impact on almonertinib resistance is unknown. This study aimed to explore the correlation between CAFs and almonertinib resistance in non-small cell lung cancer (NSCLC).
View Article and Find Full Text PDFMicroSphere 3D Structures Delay Tissue Senescence through Mechanotransduction.
ACS Nano
January 2025
Department of Orthopedics, The First Affiliated Hospital of Soochow University, 899 Pinghai Road, Soochow, Jiangsu 215000, China.
The extracellular matrix (ECM) stores signaling molecules and facilitates mechanical and biochemical signaling in cells. However, the influence of biomimetic "rejuvenation" ECM structures on aging- and degeneration-related cellular activities and tissue repair is not well understood. We combined physical extrusion and precise "on-off" alternating cross-linking methods to create anisotropic biomaterial microgels (MicroRod and MicroSphere) and explored how they regulate the cell activities of the nucleus pulposus (NP) and their potential antidegenerative effects on intervertebral discs.
View Article and Find Full Text PDFNicotine enhances the stemness and tumorigenicity in intestinal stem cells via Hippo-YAP/TAZ and Notch signal pathway.
Elife
January 2025
Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Cigarette smoking is a well-known risk factor inducing the development and progression of various diseases. Nicotine (NIC) is the major constituent of cigarette smoke. However, knowledge of the mechanism underlying the NIC-regulated stem cell functions is limited.
View Article and Find Full Text PDF[Study on the protective effect of acupuncture on poor ovarian response in mice].
Zhen Ci Yan Jiu
October 2024
College of Acupuncture-Moxibustion and Massage, Shanxi University of Traditional Chinese Medicine, Jinzhong 030619, Shanxi Province.
Article Synopsis
- The study aimed to investigate how acupuncture might protect ovarian function in mice with poor ovarian response (POR) by examining its effects on specific molecules in the Hippo signaling pathway, focusing on reducing ovarian cell death.
- Mice were divided into three groups: normal control, POR model (induced by a specific substance), and acupuncture-treated. Acupuncture was administered over ten days, and various physiological and biochemical parameters were measured to assess ovarian health.
- Results indicated that the POR model group showed increased hormonal imbalances and estrous cycle disorders compared to the normal group, suggesting a need for therapeutic interventions like acupuncture to mitigate these effects.
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