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Correcting a pathogenic mitochondrial DNA mutation by base editing in mice.
Sci Transl Med
January 2025
Graduate Program in Human Genetics, University of Miami Miller School of Medicine, 1501 NW 10th Avenue (M-860), Miami, FL 33136, USA.
Primary mitochondrial disorders are most often caused by deleterious mutations in the mitochondrial DNA (mtDNA). Here, we used a mitochondrial DddA-derived cytosine base editor (DdCBE) to introduce a compensatory edit in a mouse model that carries the pathological mutation in the mitochondrial transfer RNA (tRNA) alanine (mt-tRNA) gene. Because the original m.
View Article and Find Full Text PDFCorrection: Total syntheses of Kavaratamide A and 5--Kavaratamide A.
Org Biomol Chem
January 2025
State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Nankai University, Tianjin 300350, People's Republic of China.
Correction for 'Total syntheses of Kavaratamide A and 5--Kavaratamide A' by Tieshun Ren , , 2025, https://doi.org/10.1039/d4ob01409j.
View Article and Find Full Text PDFSource-specific bias correction of US background and anthropogenic ozone modeled in CMAQ.
Geosci Model Dev
November 2024
School of Civil and Environmental Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA.
United States (US) background ozone (O) is the counterfactual O that would exist with zero US anthropogenic emissions. Estimates of US background O typically come from chemical transport models (CTMs), but different models vary in their estimates of both background and total O. Here, a measurement-model data fusion approach is used to estimate CTM biases in US anthropogenic O and multiple US background O sources, including natural emissions, long-range international emissions, short-range international emissions from Canada and Mexico, and stratospheric O.
View Article and Find Full Text PDFHow To Correct Erroneous Symmetry-Breaking in Coarse-Grained Constant-pH Simulations.
J Chem Theory Comput
January 2025
Institute for Computational Physics, University of Stuttgart, Allmandring 3, Stuttgart 70569, Germany.
The constant-pH Monte Carlo method is a popular algorithm to study acid-base equilibria in coarse-grained simulations of charge regulating soft matter systems including weak polyelectrolytes and proteins. However, the method suffers from systematic errors in simulations with explicit ions, which lead to a symmetry-breaking between chemically equivalent implementations of the acid-base equilibrium. Here, we show that this artifact of the algorithm can be corrected a-posteriori by simply shifting the pH-scale.
View Article and Find Full Text PDFCorrection: Structure, dynamic, and free energy analyses of 5-hydroxymethylfurfural in aprotic solvents and imidazolium ionic liquids using all-atom molecular dynamics simulations.
Phys Chem Chem Phys
January 2025
Department of Chemical Engineering, Indian Institute of Technology Jodhpur, Jodhpur-342037, India.
Correction for 'Structure, dynamic, and free energy analyses of 5-hydroxymethylfurfural in aprotic solvents and imidazolium ionic liquids using all-atom molecular dynamics simulations' by Sweta Jha , , 2024, , 28417-28430, https://doi.org/10.1039/D4CP02914C.
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