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Role of the Mobile Active Site Flap in IMP Dehydrogenase Inhibitor Binding.
ACS Infect Dis
January 2025
Department of Chemistry, Brandeis University, Waltham, Massachusetts 02454, United States.
Inosine 5'-monophosphate dehydrogenase (IMPDH) is a promising antibiotic target. This enzyme catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5'-monophosphate (XMP), which is the rate-limiting step in guanine nucleotide biosynthesis. Bacterial IMPDH-specific inhibitors have been developed that bind to the NAD site.
View Article and Find Full Text PDFEnvironmental desiccation stress induces viable but non culturable state in Neisseria meningitidis.
Arch Microbiol
January 2025
Symbiosis School of Biological Sciences, Symbiosis International (Deemed University)Lavale, Pune, Maharashtra, 412115, India.
Environmental factors play a crucial role in bacterial virulence. During transmission, in a non-host environment bacteria are exposed to various environmental stress which could alter bacterial physiology and virulence. N.
View Article and Find Full Text PDFThe C-terminal structure of the N6-methyladenosine deaminase YerA and its role in deamination.
Biochem J
January 2025
The Sun Yat-Sen University, Guangzhou, China.
The N6-methyladenine (6mA) modification is an essential epigenetic marker and plays a crucial role in processes, such as DNA repair, replication, gene expression regulation, etc. YerA from Bacillus subtilis is considered a novel class of enzymes capable of catalyzing the deamination of 6mA to produce hypoxanthine. Despite the significance of this type of enzymes in bacterial self-defense systems and potential applications as a gene-editing tool, the substrate specificity, the catalytic mechanism and the physiological function of YerA are currently unclear due to the lack of structural information.
View Article and Find Full Text PDFAntibacterial properties of elastomers modified with chitosan.
Acta Bioeng Biomech
June 2024
2AGH University of Krakow, Faculty of Materials Science and Ceramics, Kraków, Poland.
Bacterial infections pose a serious threat to human health. For many years, there has been a search for materials that would inhibit their development. It was decided to take a closer look at various elastomeric materials with the addition of chitosan.
View Article and Find Full Text PDFSpectrum of Dermatoses Affecting the Lower Leg and Foot in an Outpatient Clinic at a Tertiary Care Hospital.
Adv Skin Wound Care
January 2025
At ESIC Medical College & Hospital, Faridabad, Haryana, India, Shanta Passi, MD, is Associate Professor, Department of Dermatology, Venereology, & Leprology; Deepika Uikey, MD, is Assistant Professor, Department of Dermatology, Venereology, & Leprology; and Manoj Kumar, MD, is Assistant Professor, Department of Psychiatry.
Background: Infective and noninfective dermatoses of the lower leg and foot can be attributed to factors such as infections, blood stagnation, chemical contact, and abnormal mechanics. These factors make the lower leg and foot more susceptible to microbial infections, contact dermatitis, stasis eczema, ulcers, corns, and calluses.
Objective: To identify the patterns of infective and noninfective dermatoses on the lower leg and foot.
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