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Genomics-based timely detection of dengue virus type I genotypes I and V in Uruguay.
Heliyon
November 2024
Laboratorio de Virus Emergentes/reemergentes. Unidad de Virología, Departamento de Laboratorios de Salud Pública, Portugal.
This study details a genomics-based approach for the early detection of mosquito-borne pathogens, marked by Uruguay's first ever complete genomic sequencing of Dengue Virus type I genotypes I and V. This pioneering effort has facilitated the prompt identification of these genotypes within the country, enabling Uruguayan public health authorities to develop timely and effective response strategies. Further integrated into this approach is a climate-driven suitability measure, closely associated with Dengue case reports and indicative of the local climate's role in the virus's transmission in the country within the changing climate context.
View Article and Find Full Text PDFA Y chromosome-linked genome editor for efficient population suppression in the malaria vector Anopheles gambiae.
Nat Commun
January 2025
Department of Life Sciences, Imperial College London, London, UK.
Genetic control - the deliberate introduction of genetic traits to control a pest or vector population - offers a powerful tool to augment conventional mosquito control tools that have been successful in reducing malaria burden but that are compromised by a range of operational challenges. Self-sustaining genetic control strategies have shown great potential in laboratory settings, but hesitancy due to their invasive and persistent nature may delay their implementation. Here, instead, we describe a self-limiting strategy, designed to have geographically and temporally restricted effect, based on a Y chromosome-linked genome editor (YLE).
View Article and Find Full Text PDFPatrick Manson: A Physician Pioneer in Parasitology Research.
Cureus
October 2024
Preventive and Social Medicine, Pondicherry Institute of Medical Sciences, Puducherry, IND.
Article Synopsis
- Patrick Manson, a physician-scientist active in China from 1866 to 1889, made key discoveries about the transmission of tropical infectious diseases, particularly recognizing the role of vectors in human disease transmission.
- He demonstrated that microfilariae, responsible for elephantiasis, have a nocturnal presence in the blood, transforming in mosquitoes, which act as vectors in their life cycle.
- Manson's work laid the groundwork for modern vector control strategies and he significantly contributed to medical education in Asia, establishing important institutions like the Alice Memorial Hospital and the Hong Kong College of Medicine for Chinese.
Comprehensive evaluation on progressive development strategies in DENV surveillance and monitoring infection rate among vector population.
J Vector Borne Dis
July 2024
Department of Life Science & Bio-Informatics, Assam University Diphu Campus, Diphu, Assam, India.
Article Synopsis
- * Recent outbreaks have surged due to a combination of environmental changes and human activities, along with a lack of effective control measures leading to higher morbidity and mortality rates.
- * The need for improved detection methods for infected mosquito populations is critical for predicting outbreaks and implementing timely vector control strategies; the text discusses both established and emerging technologies for vector detection.
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