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Synthesis and biological evaluation of MS-347a derivatives against plant pathogenic fungi based on a strategy of gene introduction.
J Pestic Sci
November 2024
Graduate School of Infection Control Sciences, Kitasato University.
Our group previously identified MS-347a () as a new fungicide candidate from the culture broth of the mutant strain, sp. KTF-0058, which had the gene inserted. This mutant strain was able to produce a sufficient supply of , allowing for its use to investigate the structure-activity relationship.
View Article and Find Full Text PDFCitrus transcription factor CsERF1 is involved in the response to citrus tristeza disease.
Front Plant Sci
January 2025
National Citrus Engineering and Technology Research Center, Citrus Research Institute, Southwest University/Integrative Science Center of Germplasm Creation in Western China (CHONGQING) Science City, Citrus Research Institute, Southwest University, Chongqing, China.
Introduction: Citrus tristeza virus (CTV) is a threat to the citrus production and causes severe economic losses to the citrus industry. Ethylene response factors (ERFs) play important roles in plant growth and stress responses. Although ERF genes have been widely studied in model plants, little is known about their role in biological stress responses in fruit trees, such as citrus.
View Article and Find Full Text PDFALS Motor Observational Telemedicine Objective Rasch-Built Assessment: A Quantitative Scale for the Era of Teleneurology.
Neurol Clin Pract
April 2025
Department of Neurology, Emory University School of Medicine, Atlanta, GA.
Background And Objectives: Telemedicine has become a mainstay of ALS clinical care, but there is currently no standardized approach for assessing and tracking changes to the neurologic examination in this format. The goal of this study was to create a standardized telemedicine-based motor examination scale to objectively and reliably track ALS progression and use Rasch methodology to validate the scale and improve its psychometric properties.
Methods: A draft telemedicine examination scale with 25 items assessing movement in the bulbar muscles, neck, trunk, and extremities was created by an ALS expert panel, incorporating input from patient advisors.
Effective and Engaging Active Learning in the Medical School Classroom: Lessons from Case-Based Collaborative Learning.
J Med Educ Curric Dev
January 2025
Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States.
Large group collaborative teaching approaches are rapidly gaining popularity in undergraduate medical education. The case-based collaborative Learning (CBCL) pedagogy was instituted for pre-clerkship teaching at Harvard Medical School in 2015 with subsequent implementation at other medical schools. CBCL emphasizes inductive reasoning, integrates basic and clinical sciences, stimulates curiosity, and fosters teamwork.
View Article and Find Full Text PDFConcealed penis: A review of multilevel classification and surgical reconstruction techniques.
BJUI Compass
January 2025
Department of Urology Xiangya Hospital, Central South University Changsha China.
Concealed penis (CP), also known as hidden or buried penis, is an external genital deformity in which a normal-sized penis is covered by skin, subcutaneous tissue or fat tissue in the prepubic area, leading to abnormal exposure. This condition has significant morbidity and a negative effect on certain aspects of the patient's quality of life, including but not limited to hygiene, micturition, self-image and sexual function. Current classification systems for CP are heterogeneous, but most of these further classify CP based on their division into congenital concealed penis (CCP) and adult-acquired buried penis (AABP).
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