Objectives: The oldest old adults (90+) constitute the fastest growing demographic at highest dementia risk among older adults. Depression, a common risk factor, inherently presents with heterogeneous clinical manifestations. Here, we explored the associations of the predominant depression dimensions with cognition in the LifeAfter90 study.
Methods: The LifeAfter90 study consists of racially/ethnically diverse community-dwelling adults of >90. Cognitive assessments measured episodic memory, semantic memory, and executive function. Baseline depression was measured by the Geriatric Depression Scale-15 item (GDS-15), yielding dimensions of Dysphoria, Withdrawal-Apathy -Vigor (WAV), Anxiety, Hopelessness and Subjective Memory Complaint (SMC)). We used generalized linear mixed models to explore associations between depression dimensions, and cognitive outcomes at baseline and over time adjusting for demographic factors.
Results: The cohort (n = 960, mean age 92.4± 2.3 years, 61.56% female) was very racially and ethnically diverse with 27% of participants identifying as White, 24% as Asian, 23% as Black, and 19% as Latino. Common complaints included not identifying as "full of energy" (52.45%), preference to "stay home" (46.31%) and "dropped activity" (40.0%) and 25% reported SMC. Depression dimensions showed distinct associations with cognitive outcomes: SMC correlated with worse global cognition, executive function, and verbal episodic memory (all ps < 0.0001). Hopelessness was associated with worse executive function (p < 0.001). Over 1.2 years, baseline hopelessness showed a trend for faster decline in episodic memory (β = -0.22; p = 0.035).
Discussion: In the oldest old, specific dimensions like SMC and hopelessness, may help identify individuals at high risk for cognitive decline in this highly vulnerable population.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1093/geronb/gbaf012 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The global, regional, and national late-life depression burden and trends from 1990 to 2021: A systematic analysis for the Global Burden of Disease Study 2021.
Arch Gerontol Geriatr
January 2025
The first Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, PR China; State Key Laboratory of Traditional Chinese Medicine Syndrome, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, PR China. Electronic address:
Background: Late-life depression (LLD) represents a growing global public health concern. This study aimed to assess the worldwide burden of LLD using comprehensive data.
Methods: Leveraging the latest evidence from the Global Burden of Disease Study, we analyzed trends in LLD burden from 1990 to 2021, encompassing incidence, prevalence, and disability-adjusted life years (DALYs).
Self-perceived and measured visual function, the impact of eye-disease, wellbeing, social determinants, and personality traits in Swedish 70-year-olds-results from the Gothenburg H70 Study.
Acta Ophthalmol
January 2025
Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Purpose: To explore the potential correlation between subjective and measured visual function, as well as to analyse the influence of eye disease, socioeconomic factors and emotional dimensions.
Methods: Semi-structured interviews, physical examinations and functional tests (n = 1203). Demographics covered sex, marital status, education, household economy, smoking and alcohol.
Psoriasis severity in moderate to severe psoriatic Greek patients routinely treated with systemic treatment: a cross-sectional and retrospective chart review study (CRYSTAL-Greece).
J Dermatolog Treat
December 2025
2nd Department of Dermatology and Venereology, National and Kapodistrian University of Athens, "Attikon" University General Hospital, Athens, Greece.
Objective: To characterize the systemic treatment patterns and current state of moderate-to-severe psoriasis patients in real-world settings in Greece.
Methods: CRYSTAL-Greece was a multicenter, cross-sectional and retrospective chart review study assessing Psoriasis Area and Index (PASI), Dermatology Life Quality Index (DLQI) and EuroQol-5-Dimensions 5-Levels (EQ-5D-5L). Eligible patients were consented adults (18-75 years old) on continuous treatment with any approved systemic therapy regimen for ≥24 weeks.
Association of depression dimensions with cognitive functioning in community-dwelling oldest old adults: The LifeAfter90 study.
J Gerontol B Psychol Sci Soc Sci
January 2025
Herbert and Jacqueline Krieger Klein Alzheimer's Research Center, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
Objectives: The oldest old adults (90+) constitute the fastest growing demographic at highest dementia risk among older adults. Depression, a common risk factor, inherently presents with heterogeneous clinical manifestations. Here, we explored the associations of the predominant depression dimensions with cognition in the LifeAfter90 study.
View Article and Find Full Text PDFTurkish validation of a resilience scale from older people's perspectives: resilience scale for older adults.
PeerJ
January 2025
Department of Public Health, Ege University, İzmir, Turkey.
Background: As the global population ages and life expectancy increases, older adults encounter challenges like chronic illnesses and losing loved ones; resilience is crucial for adapting to these difficulties. This study aims to culturally and linguistically adapt the psychological resilience scale designed for older adults to the Turkish context.
Methods: This methodological study included 566 individuals aged 65 and older.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!