Purpose: The purpose of this study is to describe the inter- and intra-individual differences in the platelet concentration between blood and platelet-rich plasma (PRP) preparation, assess intersubject differences considering demographic and anthropometric variables, describe PRP code distribution and analyse intrasubject variability.
Methods: A retrospective analysis was conducted using a single-centre patient database from November 2021 to November 2023. It included patients with musculoskeletal pathologies treated with PRP injections. Primary variables were demographic characteristics (sex, age, body mass index [BMI]) and platelet concentrations in blood and PRP during treatments. Secondary analysis focused on PRP code frequency distribution and intrasubject variability according to different coding systems.
Results: Here, 686 patients met the inclusion criteria. PRP exhibited significantly higher platelet concentrations compared to blood (378.01 ± 136.25 × 10 platelets/µL vs. 221.97 ± 58.21 × 10 platelets/µL, < 0.001). Younger patients had higher platelet concentrations in both blood ( = 0.004) and PRP ( = 0.003), whereas female patients showed higher platelet concentrations only in blood ( < 0.001). The platelet concentration ratio was higher in males ( < 0.001) and those with higher BMI ( = 0.023). Significant differences were found between the existing and modified PRP coding systems ( < 0.001). Intrasubject variability was higher in PRP than in blood (coefficient of variance: 21.32 ± 17.36 in blood vs. 27.85 ± 19.10 in PRP, < 0.001).
Conclusion: Age, gender, BMI and intrasubject variations significantly affect PRP formulation, emphasizing the importance of addressing these variables for a more predictable, personalized and effective therapeutic approach.
Level Of Evidence: This is a retrospective study. Level IV.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11764439 | PMC |
| http://dx.doi.org/10.1002/jeo2.70024 | DOI Listing |
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View Article and Find Full Text PDFPurpose: The purpose of this study is to describe the inter- and intra-individual differences in the platelet concentration between blood and platelet-rich plasma (PRP) preparation, assess intersubject differences considering demographic and anthropometric variables, describe PRP code distribution and analyse intrasubject variability.
Methods: A retrospective analysis was conducted using a single-centre patient database from November 2021 to November 2023. It included patients with musculoskeletal pathologies treated with PRP injections.
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