Numerous studies have shown that hyperlipidaemia is closely related to the gut microbiota, and the study of microbiota in the treatment of hyperlipidaemia is undoubtedly a new target for the treatment and prevention of hyperlipidaemia. The efficacy of regulating the gut microecology and changing the structure of gut flora has been demonstrated by both western and traditional medication, biological therapy, and dietary exercise, so it is particularly important to study the relationship between gut microbiota and the treatment of hyperlipidaemia. In this review, we summarize the mechanism and relationship between the pathogenesis of hyperlipidaemia and gut microbiota, and the mechanism of hyperlipidaemia treatment by influencing the gut microbiota in various treatment modalities, which provides diversified therapeutic ideas and scientific basis for clinical treatment. It also triggers us to think about the relationship between gut microbiota and other diseases, and to explore the influence of gut microbiota is a goal that we still need to explore.
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http://dx.doi.org/10.3389/fmicb.2024.1520252 | DOI Listing |
Clin Rev Allergy Immunol
January 2025
Department of Pediatrics, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, 610072, Sichuan, China.
The intestinal microbiota is a complex community of organisms present in the human gastrointestinal tract, some of which can produce short-chain fatty acids (SCFAs) through the fermentation of dietary fiber. SCFAs play a major role in mediating the intestinal microbiota's regulation of host immunity and intestinal homeostasis. Respiratory syncytial virus (RSV) can cause an imbalance between anti-inflammatory and proinflammatory responses in the host.
View Article and Find Full Text PDFArch Environ Contam Toxicol
January 2025
Key Laboratory of Hangzhou City for Ecosystem Protection and Restoration, School of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou, 311121, Zhejiang, China.
Toxic effects of herbicide atrazine (ATR) have been evaluated in various aquatic organisms, but our understanding of its potential impacts in reptile species remains limited. In this study, the functional performances, and gut microbiota and liver metabolite alterations of ATR-exposed Mauremys sinensis juveniles were measured to evaluate its potential toxic effects in turtles. ATR exposure had no impact on the growth rate, but would allow turtles to right themselves more quickly.
View Article and Find Full Text PDFRheumatology (Oxford)
January 2025
School of Management, Shanxi Medical University, Taiyuan, China.
Objectives: Rheumatoid arthritis (RA) is a chronic, destructive autoimmune disorder predominantly targeting the joints, with gut microbiota dysbiosis being intricately associated with its progression. The aim of the present study was to develop of effective early diagnostic methods for early RA based on gut microbiota.
Methods: A cohort comprising 262 RA patients and 475 healthy controls (HCs) was recruited.
The gut microbiome is a complex system that directly interacts with and influences many systems in the body. This delicate balance of microbiota plays an important role in health and disease and is highly influenced by lifestyle factors and the surrounding environment. As further research emerges, understanding the full potential of the gut microbiome and the impact of using nutraceuticals to positively influence its function may open the door to greater therapeutic outcomes in the treatment and prevention of disease.
View Article and Find Full Text PDFJ Agric Food Chem
January 2025
Institute of Food Sciences and Technology, National Taiwan University, Taipei 10617, Taiwan.
Curcuminoids, found in turmeric ( L.), include curcumin (CUR), demethoxycurcumin (DMC), and bisdemethoxycurcumin (BDMC). Although CUR and DMC are well-studied, the anti-inflammatory effects of BDMC remain less explored.
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