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Stable-isotope resolved metabolomics (SIRM) is a powerful approach for characterizing metabolic states in cells and organisms. By incorporating isotopes, such as C, into substrates, researchers can trace reaction rates across specific metabolic pathways. Integrating metabolomics data with gene expression profiles further enriches the analysis, as we demonstrated in our prior study on glioblastoma metabolic symbiosis.

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Correlation between maxillary defect and facial asymmetry.

Int J Oral Maxillofac Surg

January 2025

Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing, China; National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing, China; National Clinical Research Center for Oral Diseases, Beijing, China. Electronic address:

The aim of this study was to evaluate the correlation between maxillary defects and facial asymmetry, and to establish categories for visual perception of facial asymmetry. The facial data of 47 patients who underwent maxillary resection due to tumors were captured using stereophotogrammetry. Facial asymmetry was measured using a landmark-independent method and assessed with a Likert scale.

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Osseointegration for transfemoral amputees: Influence of femur length and implant sizing on bone-implant contact and alignment.

Injury

January 2025

Department of Orthopedic Surgery, McGovern Medical School, UTHealth Science Center at Houston, 5420 West Loop S. Suite 1300, Bellaire, TX, 77401, USA. Electronic address:

Introduction: Clinical data on osseointegration (OI) for limb replacement indicates a concerning increase in mechanical complications after five years post-implantation. Since adequate bone-implant contact and proper implant alignment are critical factors for successful osseointegration, it is essential to identify the factors influencing these outcomes. This study aimed to assess the effects of residual femur length and implant sizing on bone-implant contact and implant alignment.

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Significance: Laparoscopic surgery presents challenges in localizing oncological margins due to poor contrast between healthy and malignant tissues. Optical properties can uniquely identify various tissue types and disease states with high sensitivity and specificity, making it a promising tool for surgical guidance. Although spatial frequency domain imaging (SFDI) effectively measures quantitative optical properties, its deployment in laparoscopy is challenging due to the constrained imaging environment.

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[This corrects the article DOI: 10.1039/C9RA10485B.].

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