Introduction: Veno-occlusive disease/sinusoidal obstruction syndrome (VOD/SOS) is a potentially life-threatening condition characterised by obstruction of the small veins of the liver. Although typically associated with haematopoietic stem cell transplantation, VOD/SOS may also occur following intensive multimodal chemotherapy regimens. In children, symptoms of VOD/SOS are refractory thrombocytopaenia, weight gain, hepatomegaly, ascites and fluid retention, hyperbilirubinaemia and sometimes right upper quadrant pain.
Methods: Here, we present a case series of six paediatric patients with acute lymphoblastic leukaemia who developed severe VOD/SOS while receiving standard AIEOP-BFM ALL protocol treatment.
Results/conclusions: All patients responded promptly to defibrotide treatment and exhibited favourable clinical outcomes.
Trial Registration: The authors have confirmed clinical trial registration is not needed for this submission.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11756966 | PMC |
| http://dx.doi.org/10.1002/jha2.1094 | DOI Listing |
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Introduction: Veno-occlusive disease/sinusoidal obstruction syndrome (VOD/SOS) is a potentially life-threatening condition characterised by obstruction of the small veins of the liver. Although typically associated with haematopoietic stem cell transplantation, VOD/SOS may also occur following intensive multimodal chemotherapy regimens. In children, symptoms of VOD/SOS are refractory thrombocytopaenia, weight gain, hepatomegaly, ascites and fluid retention, hyperbilirubinaemia and sometimes right upper quadrant pain.
View Article and Find Full Text PDFA case of late-onset sinusoidal obstruction syndrome diagnosed histologically before meeting diagnostic criteria.
Int J Hematol
January 2025
Department of Hematology, Nagaoka Red Cross Hospital, 2-297-1, Senshu, Nagaoka, 940-2085, Japan.
Sinusoidal obstruction syndrome (SOS), also known as hepatic veno-occlusive disease (VOD), is a life-threatening complication of hematopoietic stem cell transplantation. In severe cases, SOS/VOD progresses to multiple organ failure with a mortality rate higher than 80%. Early diagnosis and treatment based on severity assessment improve the prognosis of severe SOS/VOD, but conventional diagnostic criteria may be insufficient for an early diagnosis.
View Article and Find Full Text PDFBurden of illness of non-hematopoietic stem cell transplant-related hepatic sinusoidal obstruction syndrome: A systematic review.
Heliyon
October 2024
Jazz Pharmaceuticals, Oxford, UK.
Background: Sinusoidal obstruction syndrome (SOS)/veno-occlusive disease (VOD) is generally associated with hematopoietic cell transplant (HCT), but little is known about this condition outside the HCT setting. This systematic review examines the burden of illness and current management approaches in non-HCT SOS/VOD.
Methods: We searched Embase, Medline, and grey literature sources for non-HCT SOS/VOD studies published 2002-2023.
Transjugular Liver Biopsy: The Key to a Rare Etiology of Cholestatic Hepatitis after Bone Marrow Transplantation.
GE Port J Gastroenterol
December 2024
Serviço de Gastrenterologia, Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisboa, Portugal.
Article Synopsis
- Hematopoietic stem cell transplantation (HSCT) can lead to serious complications like sinusoidal obstruction syndrome (SOS) and graft-versus-host disease (GVHD), which may show overlapping symptoms but rarely occur together.
- A case of a 29-year-old male with acute myeloid leukemia experienced hyperbilirubinemia and signs of SOS early after HSCT, followed by the development of GVHD affecting his skin, intestines, and liver.
- The complex nature of this case highlights the need for careful diagnostics, including liver hemodynamic studies and biopsies, to distinguish between SOS and GVHD, as both conditions can severely impact patient outcomes.
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