Deep brain stimulation (DBS) is a well-established treatment for both neurological and psychiatric disorders. Directional DBS has the potential to minimize stimulation-induced side effects and maximize clinical benefits. Many new directional leads, stimulation patterns and programming strategies have been developed in recent years. Therefore, it is necessary to review new progress in directional DBS. This paper summarizes progress for directional DBS from the perspective of directional DBS leads, stimulation patterns, and programming strategies which are three key elements of DBS systems. Directional DBS leads are reviewed in electrode design and volume of tissue activated visualization strategies. Stimulation patterns are reviewed in stimulation parameters and advances in stimulation patterns. Programming strategies are reviewed in computational modeling, monopolar review, direction indicators and adaptive DBS. This review will provide a comprehensive overview of primary directional DBS leads, stimulation patterns and programming strategies, making it helpful for those who are developing DBS systems.
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http://dx.doi.org/10.1007/s11571-024-10210-0 | DOI Listing |
J Ginseng Res
January 2025
Department of Oriental Medicine Biotechnology, Graduate School of Biotechnology, Kyung Hee University, Global Campus, Yongin, Gyeonggi-do, Republic of Korea.
Background: Korean Red Ginseng and ginsenosides have been studied for their efficacy against various diseases, including those related to aging. However, most aging studies use D-galactose to induce aging, which often does not accurately represent natural aging. This study aimed to verify improvements in auditory, cognitive, and liver function through administering red ginseng to an 18-month-old naturally aging mouse model.
View Article and Find Full Text PDFFront Mol Biosci
January 2025
Department of Agricultural and Food Sciences (DISTAL), University of Bologna, Cesena, Italy.
Introduction: Current intestinal models lack the mechanical forces present in the physiological environment, limiting their reliability for nanotoxicology studies. Here, we developed an enhanced Caco-2/HT29-MTX-E12 co-culture model incorporating orbital mechanical stimulation to better replicate intestinal conditions and investigate nanoparticle interactions.
Methods: We established co-cultures under static and dynamic conditions, evaluating their development through multiple approaches including barrier integrity measurements, gene expression analysis, and confocal microscopy.
J Pain Res
January 2025
Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Purpose: Spinal cord stimulation (SCS) is pivotal in treating chronic intractable pain. To elucidate the mechanism of action among conventional and current novel types of SCSs, a stable and reliable electrophysiology model in the consensus animals to mimic human SCS treatment is essential. We have recently developed a new in vivo implantable pulsed-ultrahigh-frequency (pUHF) SCS platform for conducting behavioral and electrophysiological studies in rats.
View Article and Find Full Text PDFFront Neurol
January 2025
Department of Rehabilitation Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Restoration of independent walking ability is the primary objective of stroke rehabilitation; however, not all patients achieve this goal due to diverse impairments in the paretic lower limb and compensatory mechanisms that lead to an asymmetrical and mechanically inefficient gait. This investigation aimed to examine alterations in cortical activation in post-stroke patients while walking with a wearable two-channel functional electrical stimulation (FES) in comparison to walking without FES. This observational study was conducted to discern distinct activation patterns in 19 stroke patients during sessions with and without FES, while using functional near-infrared spectroscopy (fNIRS) to monitor changes in blood oxygen levels.
View Article and Find Full Text PDFInt Arch Otorhinolaryngol
January 2025
Department of Otolaryngology, Hospital das Clínicas, Faculty of Medicine, Universidade de São Paulo, São Paulo, SP, Brazil.
Adults with cochlear implants (CIs) need periodic programming of their speech processors to take advantage of alternative adjustments. However, this requires patients to attend the CI center in person. To evaluate the feasibility of speech processor (SP) self-programming with remote assistance in CI users.
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