Middle cerebral artery (MCA) aneurysms remain excellent candidates for microsurgical treatment, despite proliferation of new endovascular tools. Nonetheless, patients desire less invasive options for permanent, durable treatment of their aneurysms; this is particularly the case for those presenting without subarachnoid hemorrhage, and those with multiple aneurysms that may require several surgical approaches. Keyhole craniotomies, when properly utilized in well-selected patients, allow for minimally invasive treatment of both ruptured and unruptured cerebral aneurysms, including those harboring bilateral aneurysms which may be treated from a single approach. Middle cerebral artery bifurcation aneurysms are ideal aneurysms for application of the keyhole concept: they reside at depth from the skull under a direct, linear path of access; obtaining early proximal control of the in-flow vessel can be accomplished with minimal further dissection at the depth of a narrow corridor; there are few perforators that require dissection; a properly placed craniotomy exposes the entire proximal sylvian fissure as well as the contralateral sylvian contents; sharp dissection of the sylvian fissure further expands the corridor which can be illuminated with lighted instruments as needed; and, conversion to a larger craniotomy can be easily performed is bailout is necessary. A relative contraindication of this approach is if both aneurysms are laterally projecting, although in experienced hands even this remains only a relative contraindication. A possible potential complication that should be prepared for is intraoperative rupture of the distal aneurysm but as demonstrated in this video, it is critical that the surgeon obtain proximal and distal control of the most distal aneurysm as would be obtained from an ipsilateral approach. In this video we demonstrate the use of this approach for bilateral unruptured MCA aneurysms, highlighting nuances for successful performance of this operation.
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http://dx.doi.org/10.1016/j.wneu.2025.123702 | DOI Listing |
Brain Struct Funct
January 2025
Department of Radiology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, Jiangxi Province, China.
A significant proportion of patients who have recovered from COVID-19 suffer from persistent symptoms, referred to as "post-acute sequelae of SARS-CoV-2 infection (PASC)". Abnormal brain intrinsic activity has been observed in PASC patients, but the patterns of frequency-dependent intrinsic activity in the PASC and non-PASC (recovered COVID-19 patients without persistent symptoms) groups and their association with neuropsychiatric sequelae remain unclear in PASC. Twenty-nine PASC patients, 27 non-PASC subjects, and 31 healthy controls (HCs) were recruited.
View Article and Find Full Text PDFExp Brain Res
January 2025
Center of Neurology, Division of Neuropsychology, Hertie-Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.
Vibrating muscles to manipulate proprioceptive input creates the sensation of an apparent change in body position. This study investigates whether vibrating the right biceps muscle has similar effects as vibrating the left posterior neck muscles. Based on previous observations, we hypothesized that both types of muscle vibration would shift the perception of healthy subjects' subjective straight-ahead (SSA) orientation in the horizontal plane to the left.
View Article and Find Full Text PDFAm J Forensic Med Pathol
January 2025
County of Santa Clara, Medical Examiner-Coroner Office, San Jose, CA.
There are few reports that discuss the nebulous entity known as posttraumatic subacute meningitis. Herein, we describe a case where a male was found deceased with Streptococcus pyogenes meningitis 7 days after experiencing head trauma inflicted with a tow chain. Computed tomography scan prior to death revealed a scalp laceration with subcutaneous gas and a subdural hematoma.
View Article and Find Full Text PDFHum Brain Mapp
February 2025
Department of Neurology, Washington University in St. Louis, St. Louis, Missouri, USA.
Neurodegeneration is presumed to be the pathological process measure most proximal to clinical symptom onset in Alzheimer Disease (AD). Structural MRI is routinely collected in research and clinical trial settings. Several quantitative MRI-based measures of atrophy have been proposed, but their low correspondence with each other has been previously documented.
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