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Effect of Perioperative Immunonutrition on Outcomes in Gastric Cancer Surgery Patients: A Systematic Review and Evidence Map.
Clin Nutr ESPEN
March 2025
Xuanwu Hospital, Capital Medical University, Beijing, China; School of Nursing, Capital Medical University, Beijing, China. Electronic address:
Background: Tumors and surgical procedures trigger a series of metabolic responses that put gastric cancer patients at constant risk of malnutrition during the perioperative period. Meanwhile, the effectiveness of enteral immunonutrition (EIN) for these patients remains a subject of ongoing debate.
Objective: This systematic review and evidence map aim to retrieve randomized controlled trials (RCTs) on perioperative EIN interventions in gastric cancer patients undergoing surgery and evaluate their effectiveness.
Kaempferide enhances type I interferon signaling as a novel broad-spectrum antiviral agent.
Antiviral Res
March 2025
Key Laboratory of Virology and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071/430207, China; State Key Laboratory of Virology and Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan 430071/430207, China; Hubei Jiangxia Laboratory, Wuhan 430207, China. Electronic address:
Broad-spectrum antivirals (BSAs) possess unique advantages of being effective against a wide range of both existing and unpredictable emerging viral infections. The host type I interferon (IFN) response serves as a universal defense against diverse viral infections nonspecifically, providing attractive targets to develop novel BSAs. In this study, we identified the flavonoid kaempferide as an enhancer of the type I IFN activated Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway, promoting the expression of IFN stimulated genes (ISGs) and the establishment of cellular antiviral status.
View Article and Find Full Text PDFMeta-analyses of the global impact of non-antibiotic feed additives on livestock performance and health.
J Adv Res
March 2025
The Roslin Institute, University of Edinburgh, Edinburgh EH25 9RG, UK; College of Animal Science and Technology, Northwest A & F University, Yangling 712100, PR China. Electronic address:
Introduction: The impact of non-antibiotic feed additives on livestock performance and health is contingent upon a multitude of variables, including the animal species, dosage and type of feed additives, and duration of oral administration. However, there is a paucity of knowledge regarding the relationship between these factors and the performance of livestock animals.
Objectives: The objective of this study was to conduct a global meta-analysis based on a pool of empirical studies to investigate the effects of dietary additives on growth, production, blood metabolites, immunity, intestinal morphology, and the abundance of gut microbiota in livestock.
Biological evaluation of a new highly sensitive and selective fluorescent probe for hypochlorous acid and its imaging application in cell and zebrafish.
Bioorg Chem
March 2025
Biology Institute, Bioengineering Department, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250103, China. Electronic address:
Hypochlorous acid is one of the most widely distributed reactive oxygen species in vivo. It is usually used as a signal molecule to participate in various life activities such as immunity and metabolism, and plays a notable role in maintaining homeostasis. When hypochlorous acid level is abnormal in the body, it will lead to a variety of diseases, such as Parkinson's disease, Alzheimer's disease, atherosclerosis and cancer.
View Article and Find Full Text PDFRecent Advances in Paper-Based Nano-Biosensors for Water-Borne Pathogen Detection: Challenges and Solutions.
Chem Biodivers
March 2025
Bandung Institute of Technology: Institut Teknologi Bandung, Industrial Engineering, Jalan Ganesha, 40191, Bandung, INDONESIA.
Ensuring access to safe water and public health necessitates sensitive, quick, and dependable detection instruments. Conventional techniques frequently have prolonged detection durations, intricate processes, and the requirement for skilled staff. Biosensors augmented with nanomaterials provide enhanced sensitivity, specificity, and rapid detection of waterborne pathogens.
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