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Tumor-Infiltrating Lymphocytes Assessed Using the International TILs Working Group System Are Not Prognostic in Medullary Thyroid Cancer.
Thyroid
January 2025
Faculty of Medicine and Health, Northern Clinical School, Sydney Medical School, University of Sydney, Sydney, Australia.
Tumor-infiltrating lymphocytes (TILs) are a protective prognostic factor in several solid tumors and predict response to immune checkpoint inhibitor therapy. The prognostic impact of TILs in medullary thyroid cancer (MTC) is poorly understood. In this retrospective cohort study, we assessed the TILs profile of primary MTC tumors using the International TILs Working Group system and correlated this with clinicopathological prognostic variables, including the International Medullary Thyroid Cancer Grading System (IMTCGS) grade and survival outcomes.
View Article and Find Full Text PDFHepatic arterial infusion chemotherapy combined with immune checkpoint inhibitors and molecular targeted therapies for advanced infiltrative hepatocellular carcinoma: a single-center experience.
Front Immunol
January 2025
Department of Radiology, Hubei Key Laboratory of Molecular Imaging, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Background: Infiltrative hepatocellular carcinoma (HCC) remains a therapeutic challenge due to its aggressive course and poor prognosis. Hepatic arterial infusion chemotherapy (HAIC) plus immune checkpoint inhibitors (ICIs) and molecular targeted therapies (MTTs) has shown early promise for advanced HCC, but its role in advanced infiltrative HCC is unclear. This study aims to investigate the efficacy and safety of HAIC combined with ICIs and MTTs in the treatment of advanced infiltrative HCC.
View Article and Find Full Text PDFEfficacy of the nutritional support team model in the management of patients undergoing total gastrectomy combined with Roux-en-Y anastomosis.
Pak J Med Sci
January 2025
Wanqiong Zhang Department of Gastrointestinal surgery, Xingtai Central Hospital, Xingtai, Hebei Province 054000, P.R. China.
Objective: To explore the efficacy of the nutritional support team (NST) management model in patients undergoing total gastrectomy combined with Roux-en-Y anastomosis.
Methods: Clinical data of 102 patients who underwent total gastrectomy combined with Roux-en-Y anastomosis in Xingtai Central Hospital from January 2020 to October 2023 were retrospectively collected. Of 102 patients, 53 received the NST model of management (NST group), while 49 were managed by the conventional nutritional support (TN group).
Nutritional risk and HbA1c as critical risk factors and predictors of opportunistic infections in HIV-DM comorbid patients: a retrospective cross-sectional study.
Front Endocrinol (Lausanne)
January 2025
The First Ward of Internal Medicine, Public Health Clinical Center of Chengdu, Chengdu, China.
Background: The clinical characteristics and risk factors for opportunistic infections in HIV patients with concomitant diabetes mellitus are unclear and worth studying. Explore the risk factors and construct a predictive model for opportunistic infections in HIV-DM patients.
Methods: Clinical data were retrospectively collected from 1,669 HIV-DM admitted to the Public Health Clinical Center of Chengdu from December 2018 to November 2023.
Predictive value of the systemic immune inflammation index in recurrence of atrial fibrillation after radiofrequency catheter ablation.
World J Cardiol
January 2025
Department of Internal Medicine-II, Paracelsus Medical University Salzburg, Salzburg 5020, Austria.
The recurrence of atrial fibrillation (AF) in patients after successful radiofrequency catheter ablation (RFCA) appears to be an unresolved clinical issue and needs to be clearly elucidated. There are many factors associated with AF recurrence, such as duration of AF, male sex, concomitant heart failure, hemodynamic parameters, chronic obstructive pulmonary disease, hypertension, obstructive sleep apnea, hyperthyroidism, smoking and obesity. However, the inflammatory changes are strongly associated with electrical and structural cardiac remodeling, cardiac damage, myocardial fibrotic changes, microvascular dysfunction and altered reparative response.
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