Objectives: The global burden of stroke is increasing every year. Residual impairments from stroke reduce the future independence of affected patients while also increasing their susceptibility to oral health-related diseases. Oral healthcare prevention programs (OHCP) are vital in maintaining acceptable oral hygiene during rehabilitation. Dysphagia among stroke elevates the risk of ingesting oral opportunistic pathogens, potentially leading to severe conditions.
Data Sources: A systematic search was conducted in three main databases (Medline, EMBASE, CENTRAL) until November 29th, 2022.
Study Selection: We included randomized clinical trials that measure the effect of OHCP on oral health and oral opportunistic pathogens. After the systematic search (7608 articles), we conducted title/abstract selection by two independent authors, followed by full-text selection. In both cases, Cohen's kappa was calculated. Finally, we found 15 articles that were eligible for analysis.
Results: The plaque index showed a slight but non-significant reduction with the OHCP program (SMD= -2.77, CI:-6.6-1.06). In terms of the risk of oral yeast detection, there was a statistically non-significant difference between the intervention and control groups at short-term and after a 3-month follow-up (RR: 1.06, 95% CI: 0.20;5.69; RR:0.98 CI: 0.33; 2.93), respectively. For S.aureus and AGNB, there was no statistically significant difference in short-term evaluation (RR: 0.89 CI: 0.07; 11.99; RR:0.77 CI: 0.00; 888.18), respectively.
Conclusions: Current evidence did not identify that regular OHCP had a beneficial effect on oral pathogen-related diseases.
Prospero Registration: CRD42022346788 CLINICAL SIGNIFICANCE: Regular oral health care, including assistance from a dental hygienist in stroke units, is essential for preventing oral health-related diseases. Integrating into post-stroke rehabilitation can enhance overall quality of life and well-being.
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http://dx.doi.org/10.1016/j.jdent.2025.105591 | DOI Listing |
Int J Surg
January 2025
Department of Geriatrics, Zhongshan Hospital Xiamen University, Fujian, People's Republic of China.
Introduction: What interventions effectively prevent postoperative stenosis following endoscopic resection (ER) of superficial esophageal cancer? This study aimed to identify effective interventions or combinations through a systematic review and network meta-analysis.
Methods: Six databases were systematically searched for eligible studies up to 30 April 2023, on interventions to prevent esophageal stenosis post-ER. Odds ratios (ORs) evaluated stenosis rate (primary outcome) and complications (secondary outcome), while mean differences (MD) evaluated endoscopic balloon dilatation (EBD) sessions post-stenosis.
ACS Nano
January 2025
Department of Infectious Diseases, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.
Nonantibiotic strategies are urgently needed to treat acute drug-resistant bacterial pneumonia. Recently, nanomaterial-mediated bacterial cuproptosis has arisen widespread interest due to its superiority against antibiotic resistance. However, it may also cause indiscriminate and irreversible damage to healthy cells.
View Article and Find Full Text PDFDiscov Oncol
January 2025
Department of Stomatology, Hangzhou Linping District First People's Hospital, Hangzhou, China.
Objectives: This study aims to use Mendelian randomisation to identify the causal relationship between a spectrum of 41 inflammatory cytokines and the development of oropharyngeal cancer.
Methods: This study investigated genetic variants that have been associated with oral and oropharyngeal cancer using data from a large GWAS. Inflammatory cytokine data were obtained from 8293 asymptomatic individuals.
Matern Child Health J
January 2025
Department of Epidemiology and Biostatistics, Michigan State University, Fee Hall West Wing; 909 Wilson Rd, East Lansing, MI, 48824, USA.
Background: Dental care before pregnancy is critical for preventing poor oral health, which is associated with adverse pregnancy outcomes. People with low incomes, however, may face insurance-related barriers to obtaining dental care. Medicaid expansion under the Affordable Care Act increased access to dental care utilization among adults with low incomes.
View Article and Find Full Text PDFVet Res Commun
January 2025
ICAR-National Institute of Veterinary Epidemiology and Disease Informatics (NIVEDI), Post Box No. 6450, Yelahanka, Bengaluru, Karnataka, 560119, India.
Sheeppox and Goatpox are highly contagious transboundary viral diseases of sheep and goats caused by Capripoxvirus, respectively. This study describes the development of indirect ELISA and its serodiagnostic potential as an alternative to the gold standard serum neutralization test (SNT). The homologue of vaccinia virus, ORF 117 (A27L) gene of the Romanian Fenner (RF) strain of Sheeppox virus (SPPV) was used for producing the full-length recombinant A27L (rA27L) protein (∼22 kDa) in a prokaryotic expression system.
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