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Passive dehydration reduces muscle thickness after resistance exercise.
J Sports Sci
January 2025
Department of Kinesiology and Sport Management, Texas Tech University, Lubbock, TX, USA.
Unlabelled: Dehydration-induced increased plasma osmolality (P) alters whole body fluid balance which could alter resistance exercise (RE) induced intramuscular (IM) fluid shift.
Purpose: The purpose of the current report was to investigate the effect of dehydration on RE-induced change in whole body fluid balance in resistance trained (RT) men.
Methods: Fourteen RT men performed two identical RE sessions, either in a hydrated (EUHY) or dehydrated (DEHY) state induced by a 24 hr fluid restriction.
Optogenetics has transformed the study of neural circuit function, but limitations in its application to species with large brains, such as non-human primates (NHPs), remain. A major challenge in NHP optogenetics is delivering light to sufficiently large volumes of deep neural tissue with high spatiotemporal precision, without simultaneously affecting superficial tissue. To overcome these limitations, we recently developed and tested in NHP cortex, the Utah Optrode Array (UOA).
View Article and Find Full Text PDFAlterations in the kynurenine pathway, and in particular the balance of neuroprotective and neurotoxic metabolites, have been implicated in the pathophysiology of Major Depressive Disorder (MDD) and antidepressant treatment response. In this study, we examined the relationship between changes in kynurenine pathway activity (Kynurenine/Tryptophan ratio), focusing on the balance of neuroprotective-to neurotoxic metabolites (Kynurenic Acid/Quinolinic Acid and Kynurenic Acid/3-Hydroxykynurenine ratios), and response to 8 weeks of selective serotonin reuptake inhibitor (SSRI) treatment, including early changes four weeks after SSRI initiation. Additionally, we examined relationships between kynurenine metabolite ratios and three promising biomarkers of depression and antidepressant response: amygdala/hippocampal volume, and glutamate metabolites in the anterior cingulate cortex.
View Article and Find Full Text PDFGait, balance, and physical performance as markers of early Alzheimer's disease and related dementia risk.
J Alzheimers Dis
January 2025
Comprehensive Center for Brain Health, Department of Neurology, Miller School of Medicine, University of Miami, Boca Raton, FL, USA.
Background: Declining physical functionality is an indicator of cognitive impairment, distinguishing normal cognition (NC) from dementia. Whether this extends to pre-dementia stages is unclear.
Objective: Assess physical performance patterns, evaluate relationships with imaging biomarkers, and identify specific measures distinguishing NC, subjective cognitive decline (SCD) and mild cognitive impairment (MCI).
Balancing Volume and Outcomes: Insights and Cautions from a Multi-State Analysis of Care for Infants Born Very Preterm.
J Pediatr
January 2025
Division of Neonatology, University of California San Diego, La Jolla, CA.
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