Cardiovascular disease (CVD) is caused by the abnormal functioning of the heart which results in a high mortality rate across the globe. The accurate and early prediction of various CVDs from the electrocardiogram (ECG) is vital for the prevention of deaths caused by CVD. Artificial intelligence (AI) is used to categorize and accurately predict various CVDs. Among different AI-based techniques, deep learning (DL)--based approaches are more effective in classifying various CVDs because they extract characteristics directly from the huge amounts of data needed to train the DL network. This paper proposes and compares the performance of a one-dimensional (1D), two-dimensional (2D) convolutional neural network (CNN), and a multi-branch convolutional neural network (MB-CNN) to classify various CVDs, namely, dilated cardiomyopathy (DCM), hypertrophic cardiomyopathy (HCM), myocardial infarction (MI) and coronary artery disease (CAD) from spectrograms of one-dimensional (1D) ECG records. The 1D ECG records are classified using a 1D CNN is proposed which achieves a maximum performance of 97.60 %. To boost performance, the 1D ECG recordings are converted into 2D-ECG spectrograms via the continuous wavelet transform (CWT) and classified based on the proposed 2D-CNN with a maximum accuracy of 98.46 %. To further improve the classification performance, the obtained 2D- ECG spectrograms are classified using the proposed MB-CNN containing multiple branches which can capture various degrees of abstraction leading to a precise classification. The proposed approach using the MB-CNN model obtains an average test accuracy of 99.34 % for the classifications of five types of CVDs and 99.22 % for the classification of 5 classes of ECGs in the MIT-BIH database.
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http://dx.doi.org/10.1016/j.compbiomed.2025.109737 | DOI Listing |
Biochem Biophys Res Commun
January 2025
Department of Ultrasonography, Fuwai Yunnan Hospital, Chinese Academy of Medical, Sciences/Affiliated Cardiovascular Hospital of Kunming Medical University, Kunming, 650102, China. Electronic address:
Pulmonary arterial hypertension (PAH) is a syndrome characterized by increased pulmonary vascular resistance and elevated pulmonary artery pressure, ultimately leading to right heart failure and even death. Increasing evidence implicates the fat mass and obesity-associated protein (FTO) in various metabolic and inflammatory pathways; however, its role in pulmonary endothelial function and PAH remains largely unexplored. In this study, we examined the effects of endothelial cell-specific FTO knockout on PAH development.
View Article and Find Full Text PDFJMIR Form Res
January 2025
Department of Design Innovation, College of Design, University of Minnesota, Twin Cities, Minneapolis, MN, United States.
Background: Congenital heart disease (CHD) is a birth defect of the heart that requires long-term care and often leads to additional health complications. Effective educational strategies are essential for improving health literacy and care outcomes. Despite affecting around 40,000 children annually in the United States, there is a gap in understanding children's health literacy, parental educational burdens, and the efficiency of health care providers in delivering education.
View Article and Find Full Text PDFDeep venous thrombosis (DVT) has insidious clinical symptoms, and only a few patients suffer from lower limb swelling, tenderness and dorsal flexion pain. We aimed to explore the ultrasonographic features and risk factors of postoperative lower limb DVT in patients with lower limb fractures. Ninety patients with lower limb fractures admitted from January 1st, 2021 to June 30th, 2023 were selected.
View Article and Find Full Text PDFNeurology
February 2025
Department of Neurology, Department of Stroke, University Hospital Cleveland Medical Center, Case Western Reserve University, Cleveland, OH.
Background And Objectives: Although previous trials have established the efficacy and safety of endovascular thrombectomy (EVT) in large ischemic core strokes, most of them excluded patients with extracranial internal carotid artery (e-ICA) occlusion. We aimed to compare outcomes in patients with e-ICA occlusion and large ischemic core infarcts treated with EVT vs medical management (MM).
Methods: This was a secondary analysis of the SELECT2 trial, a randomized controlled trial conducted at 31 international sites.
Stroke
February 2025
Neurovascular Research Unit, Pharmacology Department, Complutense Medical School, Instituto Investigación Hospital 12 Octubre, Madrid, Spain (G.D., B.D., A.M., J.M.P., I.L.).
Background: Acute ischemic stroke treatment typically involves tissue-type plasminogen activator (tPA) or tenecteplase, but about 50% of patients do not achieve successful reperfusion. The causes of tPA resistance, influenced by thrombus composition and timing, are not fully clear. Neutrophil extracellular traps (NETs), associated with poor outcomes and reperfusion resistance, contribute to thrombosis.
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