ALTERNATIVE BIOLOGICAL MODELS FOR EVALUATION OF THE TOXIC, GENOTOXIC AND MUTAGENIC POTENTIAL OF Ectatomma brunneum Smith VENOM.

Toxicon

Faculty of Biological and Environmental Sciences, Federal University of Grande Dourados (UFGD), Dourados-Itahum Highway, Km 12 - Unit II, University City, 79804-970, Dourados, MS, Brazil; Faculty of Exact Sciences and Technology, Federal University of Grande Dourados (UFGD), Dourados-Itahum Highway, Km 12 - Unit II, University City, 79804-970, Dourados, MS, Brazil.

Published: January 2025

The venom of Ectatomma brunneum is considered promising for drugs development. Therefore, it is important to evaluate its toxic potential and genetic instability using biological assays. To this end, toxicity assays were performed with Artemia salina, cytotoxicity and genotoxicity with Allium cepa and mutagenicity with Ames. The results indicated toxicity to A. salina, and no cytotoxic, genotoxic or mutagenic potential at concentrations equal to or lower than 500 μg/mL for the other tests.

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http://dx.doi.org/10.1016/j.toxicon.2025.108256DOI Listing

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