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Treating apathy in frontotemporal dementia.
Lancet Neurol
February 2025
Brain and Mind Centre, The University of Sydney, Sydney, NSW 2050, Australia; Department of Neurology, Royal Prince Alfred Hospital, Sydney, NSW, Australia.
Intranasal oxytocin for apathy in people with frontotemporal dementia (FOXY): a multicentre, randomised, double-blind, placebo-controlled, adaptive, crossover, phase 2a/2b superiority trial.
Lancet Neurol
February 2025
Department of Clinical Neurological Sciences, University of Western Ontario, London, ON, Canada; Department of Cognitive Neurology, St Joseph's Health Care London, London, ON, Canada. Electronic address:
Background: No treatments exist for apathy in people with frontotemporal dementia. Previously, in a randomised double-blind, placebo-controlled, dose-finding study, intranasal oxytocin administration in people with frontotemporal dementia improved apathy ratings on the Neuropsychiatric Inventory over 1 week and, in a randomised, double-blind, placebo-controlled, crossover study, a single dose of 72 IU oxytocin increased blood-oxygen-level-dependent signal in limbic brain regions. We aimed to determine whether longer treatment with oxytocin improves apathy in people with frontotemporal dementia.
View Article and Find Full Text PDFConsequences of COVID-19 for geriatric patients during a pandemic.
Sci Rep
January 2025
Department of Geriatric Medicine, University Duisburg-Essen, Essen, Germany.
To investigate the outcomes of geriatric COVID-19 patients in a German academic setting during the pandemic. This study included 468 consecutive geriatric patients (≥ 70 years) who tested positive for SARS-CoV-2 and were treated at the University of Duisburg-Essen from 2/2020 to 3/2021. 74 patients were transferred to a geriatric hospital and a 12-month follow-up (prospective study) was performed in 51 patients.
View Article and Find Full Text PDFCost-utility analysis of a coadjutant telemedicine intervention for fall prevention in Parkinson's disease.
Eur J Neurol
January 2025
Research Unit, Hospital Universitario Burgos, Burgos, Spain.
Background And Purpose: Adopting telemedicine (TM) enables improved access to specialized care and reduces barriers. The aim was to assess the cost-utility of a coadjutant multidisciplinary TM programme for fall prevention compared to standard in-office visits for individuals with Parkinson's disease (PD).
Methods: This was an 8-month single-blind randomized controlled trial.
Relationship between apathy/post-stroke depression and gait training in patients with stroke.
Psychogeriatrics
March 2025
Department of Rehabilitation Science, Kobe University Graduate School of Health Sciences, Kobe, Japan.
Background: We examined the effect of gait training on apathy/post-stroke depression (PSD) in patients with walking disorders after stroke, and the effect of apathy/PSD on gait reacquisition in subacute stroke.
Methods: Fifty-five participants with gait disorders after stroke underwent gait training for 6 weeks. Outcome measurements included Apathy Scale (AS), Center for Epidemiologic Studies Depression Scale (CES-D), Mini-Mental State Examination, Lower Extremity Function of Stroke Impairment Assessment Set, and Functional Independence Measure-TRANSFER and -WALK scores.
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