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Correction: Khavinson et al. Neuroprotective Effects of Tripeptides-Epigenetic Regulators in Mouse Model of Alzheimer's Disease. 2021, , 515.
Pharmaceuticals (Basel)
January 2025
Petersburg Nuclear Physics Institute Named after B.P. Konstantinov, NRC "Kurchatov Institute", 188300 Gatchina, Russia.
In the original publication [...
View Article and Find Full Text PDF[Prospects for use of short peptides in pharmacotherapeutic correction of Alzheimer's disease.].
Adv Gerontol
June 2024
Saint-Petersburg Institute of Bioregulation and Gerontology, 3 Dinamo pr., St. Petersburg 197110, Russian Federation, e-mail:
Alzheimer's disease (AD) is the most common neurodegenerative disorder, characterized by progressive cognitive decline. This review discusses current therapeutic strategies for the treatment of Alzheimer's disease, their limitations, and potential prospects. The feasibility of comprehensive approach for AD therapy is considered in contrast to the classical method in the development of therapeutic strategy.
View Article and Find Full Text PDFCorrection to: Tripeptides Restore the Number of Neuronal Spines under Conditions of In Vitro Modeled Alzheimer's Disease.
Bull Exp Biol Med
September 2017
St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia.
On the page 553 Acknowledgements should be as follows: The study was supported by the Russian Science Foundation (grant 14-25-00024-P).
View Article and Find Full Text PDF[Correction of impaired glucose tolerance using tetrapeptide (Pancragen) in old female rhesus monkeys].
Adv Gerontol
February 2018
St.Petersburg Institute of Bioregulation and Gerontology, Saint-Petersburg, 197110, Russian Federation.
The aim of the investigation was comparative study of the influence tetrapeptide Pancragen (St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg) on hormonal function of the pancreas compared to the effect of widely used hypoglycemic drug - glimepiride.
View Article and Find Full Text PDFSignificant increase of the elderly in the demographic structure of a modern society is one of the main reasons for increase in the number of patients with diabetes type 2 and impaired glucose tolerance. The purpose of this research was to study impact of Pancragen (tetrapeptide Lys-Glu-Asp-Trp) on endocrine function of the pancreas of non-human primates, female rhesus monkeys, and to elucidate the possibil- ity of its use for correction age-related dysfunction of pancreatic islet apparatus. In old animals after the glucose administration (standard dose) in control period, a reduced glucose "disappearance" rate and a higher values of insulin and C-peptide peaks (5 and 15 min after the glucose injection) were observed in comparison with young animals in similar experiments.
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