To determine if psychological factors, such as anxiety, depression, fear of movement and fear of rupture are associated with increased tendon-related disability, quantified by the Tendinopathy Severity Assessment-Achilles (TENDINS-A). Cross-sectional. Online Qualtrics survey. Sixty-eight participants (54% female) with Achilles tendinopathy and a mean (standard deviation) age of 40.1 (12.6) years. The TENDINS-A (including subscales of pain; symptoms such as stiffness; physical function), Patient Health Questionnaire-9, General Anxiety Disorder-7, Tampa Scale for Kinesiophobia and fear of tendon rupture. Associations were evaluated using generalised linear models (adjusting for age and sex), with significance accepted when < 0.05. Anxiety symptoms were positively associated with Achilles pain ( = 0.035), symptoms ( = 0.045) and physical function ( = 0.019). Depressive symptoms were negatively associated with symptoms ( = 0.045) but not pain ( = 0.078) or physical function ( = 0.429). Fear of movement was not associated with pain ( = 0.479), symptoms ( = 0.915) or physical function ( = 0.064). Fear of rupture was associated with pain ( = 0.042), but not symptoms ( = 0.797) or physical function ( = 0.509). Our research demonstrated anxiety symptoms and fear of rupture, not fear of movement or depressive symptoms, are positively associated with the severity of tendon-related disability. Therefore, clinicians should include an assessment anxiety symptoms and fear of rupture in their practice.
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J Ultrasound
January 2025
Clinical Unit of Neurology, Department of Medicine, Surgery and Health Sciences, University Hospital and Health Services of Trieste, ASUGI, University of Trieste, Strada di Fiume, 447, 34149, Trieste, Italy.
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Department of Urology, Qilu Hospital of Shandong University, 107 Wenhuaxi Road Jinan, Shandong, 250012, People's Republic of China.
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Department of Respiratory and Critical Care Medicine, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Background: Menopause is a significant phase in women's health, in which the incidence of obstructive sleep apnea (OSA) is significantly increased. Body fat distribution changes with age and hormone levels in postmenopausal women, but the extent to which changes in body fat distribution affect the occurrence of OSA is unclear.
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Sci Rep
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College of Physical Education and Health Sciences, Zhejiang Normal University, Jinhua, 321004, China.
Athlete engagement is influenced by several factors, including cohesion, passion and mental toughness. Machine learning methods are frequently employed to construct predictive models as a result of their high efficiency. In order to comprehend the effects of cohesion, passion and mental toughness on athlete engagement, this study utilizes the relevant methods of machine learning to construct a prediction model, so as to find the intrinsic connection between them.
View Article and Find Full Text PDFOncogene
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Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, 230031, China.
Ferroptosis is a unique modality of regulated cell death induced by excessive lipid peroxidation, playing a crucial role in tumor suppression and providing potential therapeutic strategy for cancer treatment. Here, we find that aldehyde dehydrogenase-ALDH3A1 tightly links to ferroptosis in squamous cell carcinomas (SCCs). Functional assays demonstrate the enzymatic activity-dependent regulation of ALDH3A1 in protecting SCC cells against ferroptosis through catalyzing aldehydes and mitigating lipid peroxidation.
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