In this research, the adhesive contact between a hard steel and a soft elastomer cylinder was experimentally studied. In the experiment, the hard cylinder was indented into the soft one, after which the two cylinders were separated. The contact area between the cylinders was elliptical in shape, and the eccentricity of this increased as the angle between the axes of the contacting cylinders decreased. Additionally, the adhesive pull-off force and the contact area increased with a decrease in the angle between the cylinders. The use of a transparent elastomer allowed for observation of the shape of the contact in real time, which facilitated the creation of videos demonstrating the complete process of contact failure and the evolution of the ellipse shape, depending on the distance between the cylinders and normal force. These findings contribute to a better understanding of adhesive interactions in elliptical contacts between cylinders and can be applied to fields such as soft robotics, material design, and bioengineering, where precise control over adhesion and contact mechanics is crucial.
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http://dx.doi.org/10.3390/ma18020375 | DOI Listing |
Sci Rep
January 2025
Department of Pharmaceutical Chemistry, Semmelweis University, Hőgyes Endre U. 9, 1092, Budapest, Hungary.
Microtiter-plate-based systems are unified platforms of high-throughput experimentation (HTE). These polymeric devices are used worldwide on a daily basis-mainly in the pharmaceutical industry-for parallel syntheses, reaction optimization, various preclinical studies and high-throughput screening methods. Accordingly, laboratory automation today aims to handle these commercially available multiwell plates, making developments focused on their modifications a priority area of modern applied research.
View Article and Find Full Text PDFBioelectrochemistry
January 2025
Shanghai Key Laboratory of Functional Materials Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237, People's Republic of China; Research Center of Analysis and Test, East China University of Science and Technology, Shanghai 200237, People's Republic of China. Electronic address:
Adenosine plays a crucial role in the cardiovascular and nervous systems of living organisms. Excessive adenosine can lead to arrhythmias or heart failure, making the accurate detection of adenosine highly valuable. Given the widespread use of sensors for detecting small molecules, we propose a sensitive electrochemical aptasensor for adenosine detection in this study.
View Article and Find Full Text PDFCurr Opin Genet Dev
January 2025
Department of Quantitative and Computational Biology, University of Southern California, Los Angeles, CA, USA. Electronic address:
Three-dimensional genome folding plays roles in gene regulation and disease. In this review, we compare and contrast recent deep learning models for predicting genome contact maps. We survey preprocessing, architecture, training, evaluation, and interpretation methods, highlighting the capabilities and limitations of different models.
View Article and Find Full Text PDFViruses
January 2025
Global Health Program, Washington State University Global Health-Kenya, Nairobi 00200, Kenya.
Human outbreaks of Middle East respiratory syndrome coronavirus (MERS-CoV) are more common in Middle Eastern and Asian human populations, associated with clades A and B. In Africa, where clade C is dominant in camels, human cases are minimal. We reviewed 16 studies (n = 6198) published across seven African countries between 2012 and 2024 to assess human MERS-CoV cases.
View Article and Find Full Text PDFThe present study aimed to evaluate the vaccine effectiveness (VE) of different doses of an inactivated coronavirus disease 2019 (COVID-19) vaccine against Omicron BA.2.2 infection in Beijing, China, 2022.
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