Inertial microfluidics, as an efficient method for the manipulation of micro-/nanoparticles, has garnered significant attention due to its advantages of high throughput, structural simplicity, no need for external fields, and sheathless operation. Common structures include straight channels, contraction-expansion array (CEA) channels, spiral channels, and serpentine channels. In this study, we developed a CEA channel embedded with hook-shaped microstructures to modify the characteristics of vortices. Through experimental studies, we investigated the particles' migration mechanisms within the proposed structure. The findings indicated that, in comparison to conventional rectangular microstructures, the particles within the hook-shaped microstructured CEA channels experienced a more pronounced influence from inertial lift forces. Moreover, the magnitude of the second flow within the novel configuration was directly proportional to the channel width, the length of the expansion segment, and the embedding depth of the microstructure. The innovative structure was subsequently employed for particle trapping, focusing, and separation. The experimental outcomes revealed focusing efficiency of up to 99.1% and sorting efficiency of up to 97%. This research holds the potential to enhance the foundational theory of Dean flows and broaden the application spectrum of inertial contraction-expansion microfluidic chips.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.3390/mi16010083 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Efficient Particle Manipulation Using Contraction-Expansion Microchannels Embedded with Hook-Shaped Arrays.
Micromachines (Basel)
January 2025
School of Mechanical and Electrical Engineering, China University of Mining and Technology, Xuzhou 221116, China.
Inertial microfluidics, as an efficient method for the manipulation of micro-/nanoparticles, has garnered significant attention due to its advantages of high throughput, structural simplicity, no need for external fields, and sheathless operation. Common structures include straight channels, contraction-expansion array (CEA) channels, spiral channels, and serpentine channels. In this study, we developed a CEA channel embedded with hook-shaped microstructures to modify the characteristics of vortices.
View Article and Find Full Text PDFfunction, assembly, and interaction of primary cell wall cellulose synthase homotrimers.
bioRxiv
February 2024
Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA 22903. Howard Hughes Medical Institute.
Plant cell walls contain a meshwork of cellulose fibers embedded into a matrix of other carbohydrate and non-carbohydrate-based biopolymers. This composite material exhibits extraordinary properties, from stretchable and pliable cell boundaries to solid protective shells. Cellulose, a linear glucose polymer, is synthesized and secreted across the plasma membrane by cellulose synthase (CesA).
View Article and Find Full Text PDFPhospholipid translocation captured in a bifunctional membrane protein MprF.
Nat Commun
May 2021
National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, PR China.
As a large family of membrane proteins crucial for bacterial physiology and virulence, the Multiple Peptide Resistance Factors (MprFs) utilize two separate domains to synthesize and translocate aminoacyl phospholipids to the outer leaflets of bacterial membranes. The function of MprFs enables Staphylococcus aureus and other pathogenic bacteria to acquire resistance to daptomycin and cationic antimicrobial peptides. Here we present cryo-electron microscopy structures of MprF homodimer from Rhizobium tropici (RtMprF) at two different states in complex with lysyl-phosphatidylglycerol (LysPG).
View Article and Find Full Text PDFTracking the attentional blink profile: a cross-sectional study from childhood to adolescence.
Psychol Res
January 2015
Infancy Studies Laboratory, Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, 197 University Avenue, Newark, NJ, 07102, USA,
This cross-sectional study is the first to examine the developmental trajectory of temporal attention control from childhood to adolescence. We used a rapid serial visual presentation paradigm, calling for the identification of two targets (T1 and T2) embedded in a distractor stream. In adults, manipulating the lag time within the target doublet typically leads to pronounced impairment in report for T2, when it follows T1 after approximately 200 ms, with one intervening distractor (lag 2); this is referred to as the attentional blink (AB).
View Article and Find Full Text PDFCompetition for cognitive resources during rapid serial processing: changes across childhood.
Front Psychol
July 2011
Center for Research on Individual Development and Adaptive Education, German Institute for International Educational Research Frankfurt am Main, Germany.
The ability to direct cognitive resources to target objects despite distraction by competing information plays an important role for the development of mental aptitudes and skills. We examined developmental changes of this ability in a cross-sectional design, using the "attentional blink" (AB) paradigm. The AB is a pronounced impairment of T2 report, which occurs when a first (T1) and second target (T2) embedded in a rapid stimulus sequence are separated by at least one distractor and occur within 500 ms of each other.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!