: Mothers of children with autism spectrum disorder (ASD) often experience significant stress, which can adversely affect their quality of life (QoL) and increase their reliance on social support. This study aimed to explore the relationship between social support and QoL among mothers of ASD children and identify associated factors. : A cross-sectional study was conducted from December 2022 to March 2023, involving 218 mothers of ASD children in Saudi Arabia. An online questionnaire was distributed via autism associations. Inclusion criteria were mothers of children under 18 diagnosed with ASD, excluding those with diagnosed mental illnesses. Social support and QoL were measured using the Multidimensional Scale of Perceived Social Support (MSPSS) and the Quality of Life in Autism Questionnaire (QoLA). Statistical analysis was performed using Jamovi software. : The mean MSPSS and QoLA scores were 4.87 and 100.88, respectively, with a significant positive correlation (Spearman's rho = 0.509, < 0.001). Social support was positively associated with higher education and negatively with having more than one autistic child. QoLA scores were significantly predicted by family income (>SAR 10,000 or US 2667) and MSPSS score ( < 0.001). : Social support enhances maternal QoL and is influenced by educational level and income, highlighting the need for targeted interventions to support mothers with multiple ASD children. While individual support is important, prioritizing societal accessibility may offer more effective long-term solutions by proactively addressing systemic challenges faced by autistic individuals and their families.
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