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Anti-SSA Ro52 and anti-Ro60 autoantibodies: association with clinical phenotypes.
Clin Exp Rheumatol
July 2024
Department of Rheumatology, Centro Hospitalar Baixo Vouga, Aveiro; Egas Moniz Health Alliance Academic Clinical Center, Aveiro; and EpiDoc Unit, Nova Medical School, NOVA University Lisbon; and Comprehensive Health Research Center, Universidade NOVA de Lisboa, Portugal.
Objectives: Anti-SSA autoantibodies can be differentiated according to their antigenic target proteins as anti-Ro60 (60 kDa) or anti-Ro52 (52 kDa). Anti-SSA(Ro60) antibodies are clearly associated with connective tissue diseases (CTD), but the clinical significance of anti-SSA(Ro52) antibodies remains unclear. The aim of the present study was to analyse the disease phenotype of patients with anti-Ro52 and/or anti-Ro60 antibodies.
View Article and Find Full Text PDFPlasma Cell-Free DNA Is a Potential Biomarker for Diagnosis of Calcific Aortic Valve Disease.
Cardiology
April 2024
Department of Cardiology, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China.
Introduction: Calcific aortic valve disease (CAVD) is the third most common cardiovascular disease in aging populations. Despite a growing number of biomarkers having been shown to be associated with CAVD, a marker suitable for routine testing in clinical practice is still needed. Plasma cell-free DNA (cfDNA) has been suggested as a biomarker for diagnosis and prognosis in multiple diseases.
View Article and Find Full Text PDFThe occult rheumatic scourge: A clinicopathological analysis of missed rheumatic heart disease.
Indian J Pathol Microbiol
November 2022
Consultant Cardiologist, Mahatma Gandhi Mission Hospitals, Mumbai, Maharashtra, India.
Aims: To study the clinical and pathological manifestations of missed cases of rheumatic heart disease (RHD) and postulate possible reasons behind a missed diagnosis.
Materials And Methods: Retrospective 20-year (2000-2019) autopsy data of chronic RHD were reviewed and patients, in whom the valvular deformities had been incidental autopsy findings, were selected. The clinical details of these patients were correlated with the morphology of the affected valves.
Imaging Characterization of Non-Rheumatoid Retro-Odontoid Pseudotumors: Comparison with Atlantoaxial Manifestation of Rheumatoid Arthritis.
Medicina (Kaunas)
September 2022
Department of Radiology, Pusan National University Hospital, 179, Gudeok-ro, Busan 49241, Korea.
Backgroundand Objectives: To date, imaging characterization of non-rheumatic retro-odontoid pseudotumors (NRROPs) has been lacking; therefore, NRROPs have been confused with atlantoaxial joint involvement of rheumatoid arthritis (RA). It is important to differentiate these two disease because the treatment strategies may differ. The purpose of this study is to characterize imaging findings of NRROPs and compare them with those of RA.
View Article and Find Full Text PDFRecurrent fulminant non-rheumatic streptococcal myocarditis proven by endomyocardial biopsy and autopsy.
J Cardiol Cases
July 2022
Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Unlabelled: A 42-year-old man with a history of acute myocarditis after streptococcal pharyngitis developed recurrent fulminant myocarditis. Endomyocardial biopsy revealed myocyte degeneration, interstitial edema, and neutrophil infiltration. The patient's cardiac function deteriorated rapidly, and he died despite mechanical circulatory support.
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