Background: Children are anxious when hospitalized due to being away from home and undergoing treatment.This anxiety has an effect on their disease process, treatment, growth and development.Children's anxiety has an effect on parents' anxiety and can lead to lower level of cooperation among the children and their parents with the treatment team.the present study aimed to compare the effect of play therapy and storytelling on the anxiety of hospitalized children.
Methods: A randomized controlled trial study with a three-group design (play therapy, storytelling and control) was conducted in 75 children aged 3 to 10 years admitted to Imam Ali Alborz Hospital of Karaj, Iran between 2022-2023.The data before and after the intervention were collected by the Spence children's anxiety scale and the face tool for anxiety assessment and analyzed by the Mixed effect model statistical method.
Results: There is a statistically significant difference between the anxiety score of the children for whom storytelling was used and control group. Also, among the two therapies of storytelling and play therapy, only storytelling therapy has a significant effect on reducing children's anxiety.Regarding the time of measuring the anxiety score(the first, second, third day after the intervention), it was found that as this time increases, the children's anxiety decreases significantly.morever, the children's gender, age, and history of hospitalization are influencing factors.
Conclusion: Play therapy and storytelling play an effective role in controlling the anxiety of hospitalized children, although storytelling had a greater role in reducing the anxiety of hospitalized children than play therapy. It is suggested to provide the necessary conditions and facilities for the implementation of these methods in children's inpatient departments.
Trial Registration: https://irct.behdasht.gov.ir/ ,IRCT20220704055367N1,13/7 /2022.
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http://dx.doi.org/10.1186/s12906-025-04767-4 | DOI Listing |
Bioorg Chem
January 2025
Department of In Vitro Carcinogenesis and Cellular Chemotherapy, Chittaranjan National Cancer Institute, 37, S. P. Mukherjee Road, Kolkata 700026, India. Electronic address:
Histone deacetylases (HDACs) play a critical role in chromatin remodelling and modulating the activity of various histone proteins. Aberrant HDAC functions has been related to the progression of breast cancer (BC), making HDAC inhibitors (HDACi) promising small-molecule therapeutics for its treatment. Hydroxamic acid (HA) is a significant pharmacophore due to its strong metal-chelating ability, HDAC inhibition properties, MMP inhibition abilities, and more.
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Mental health is inherently multidimensional, requiring a holistic approach to intervention that integrates various aspects of an individual's well-being. Spirituality, a vital component of mental health, remains under addressed in Australian mental healthcare. Spiritual care practitioners may play a key role in addressing spiritual needs in mental healthcare; however, their roles and contributions in this context remain unexplored in the extant literature.
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Department of Pathology, Faculty of Medicine, School of Health Sciences, University of Thessaly, 41500 Larissa, Greece.
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Front Biosci (Landmark Ed)
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Department of Nutrition and Dietetics, School of Health Sciences and Education, Harokopio University, 17676 Athens, Greece.
Platelet aggregation and inflammation play a crucial role in atherothrombosis. Wine contains micro-constituents of proper quality and quantity that exert cardioprotective actions, partly through inhibiting platelet-activating factor (PAF), a potent inflammatory and thrombotic lipid mediator. However, wine cannot be consumed extensively due to the presence of ethanol.
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Department of Chemistry Education, Kongju National University, 32588 Gongju, Chungcheongnam-do, Republic of Korea.
In recent years, the role of coenzymes, particularly those from the vitamin B group in modulating the activity of metalloenzymes has garnered significant attention in cancer treatment strategies. Metalloenzymes play pivotal roles in various cellular processes, including DNA repair, cell signaling, and metabolism, making them promising targets for cancer therapy. This review explores the complex interplay between coenzymes, specifically vitamin Bs, and metalloenzymes in cancer pathogenesis and treatment.
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