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Metabolic adaptations to acute glucose uptake inhibition converge upon mitochondrial respiration for leukemia cell survival.
Cell Commun Signal
January 2025
Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, 10029, USA.
One hallmark of cancer is the upregulation and dependency on glucose metabolism to fuel macromolecule biosynthesis and rapid proliferation. Despite significant pre-clinical effort to exploit this pathway, additional mechanistic insights are necessary to prioritize the diversity of metabolic adaptations upon acute loss of glucose metabolism. Here, we investigated a potent small molecule inhibitor to Class I glucose transporters, KL-11743, using glycolytic leukemia cell lines and patient-based model systems.
View Article and Find Full Text PDFHidden Urban Biodiversity: A New Species of the Genus Mittleman, 1950 (Squamata: Scincidae) from Chengdu, Sichuan Province, Southwest China.
Animals (Basel)
January 2025
CAS Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization, Ecological Restoration and Biodiversity Conservation Key Laboratory of Sichuan Province, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610213, China.
The genus Mittleman, 1950, belonging to the family Scincidae, exhibits considerable morphological convergence, complicating species delimitation and resulting in underestimated diversity. Currently, 41 species are formally recognized in this genus, although this figure likely underestimates its true richness. In this study, a new species of the genus , , is described from urban and suburban areas of Chengdu, Sichuan Province, Southwest China.
View Article and Find Full Text PDFConvergent and conserved roads lead to Rome: now archaea fill the gap of transcription termination.
Sci China Life Sci
January 2025
Archaeal Biology Center, Synthetic Biology Research Center, Shenzhen Key Laboratory of Marine Microbiome Engineering, Key Laboratory of Marine Microbiome Engineering of Guangdong Higher Education Institutes, Institute for Advanced Study, Shenzhen University, Shenzhen, 518060, China.
Cold climate-driven convergent evolution among angiosperms.
Plant Commun
January 2025
State Key Laboratory of Subtropical Silviculture, College of Forestry and Biotechnology, Zhejiang A&F University; Hangzhou 311300, China; Zhejiang International Science and Technology Cooperation Base for Plant Germplasm Resources Conservation and Utilization, Zhejiang A&F University; Hangzhou 311300, China; Provincial Key Laboratory for Non-wood Forest and Quality Control and Utilization of Its Products, Zhejiang A&F University, Hangzhou 311300, China. Electronic address:
Convergent and parallel evolution occur more frequently than previously thought. Here, we focus on the evolutionary adaptations of angiosperms to sub-zero temperatures. We begin by introducing the research history of convergent and parallel evolution, defining all independent similarities as convergent evolution.
View Article and Find Full Text PDFOsteology and functional morphology of a transitional pterosaur Dearc sgiathanach from the Middle Jurassic (Bathonian) of Scotland.
BMC Ecol Evol
January 2025
School of GeoSciences, University of Edinburgh, Edinburgh, Scotland.
Pterosaurs were the first vertebrates to evolve active flight. The lack of many well-preserved pterosaur fossils limits our understanding of the functional anatomy and behavior of these flight pioneers, particularly from their early history (Triassic to Middle Jurassic). Here we describe in detail the osteology of an exceptionally preserved Middle Jurassic pterosaur, the holotype of Dearc sgiathanach from the Isle of Skye, Scotland.
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