The healthcare sector is experiencing a digital transformation propelled by the Internet of Medical Things (IOMT), real-time patient monitoring, robotic surgery, Electronic Health Records (EHR), medical imaging, and wearable technologies. This proliferation of digital tools generates vast quantities of healthcare data. Efficient and timely analysis of this data is critical for enhancing patient outcomes and optimizing care delivery. Real-time processing of Healthcare Big Data (HBD) offers significant potential for improved diagnostics, continuous monitoring, and effective surgical interventions. However, conventional cloud-based processing systems face challenges due to the sheer volume and time-sensitive nature of this data. The migration of large datasets to centralized cloud infrastructures often results in latency, which impedes real-time applications. Furthermore, network congestion exacerbates these challenges, delaying access to vital insights necessary for informed decision-making. Such limitations hinder healthcare professionals from fully leveraging the capabilities of emerging technologies and big data analytics. To mitigate these issues, this paper proposes a Regional Computing (RC) paradigm for the management of HBD. The RC framework establishes strategically positioned regional servers capable of regionally collecting, processing, and storing medical data, thereby reducing dependence on centralized cloud resources, especially during peak usage periods. This innovative approach effectively addresses the constraints of traditional cloud processing, facilitating real-time data analysis at the regional level. Ultimately, it empowers healthcare providers with the timely information required to deliver data-driven, personalized care and optimize treatment strategies.
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http://dx.doi.org/10.1038/s41598-025-87515-5 | DOI Listing |
J Adolesc Health
January 2025
Center for Clinical Big Data and Statistics of the Second Affiliated Hospital Zhejiang University School of Medicine, School of Public Health Zhejiang University School of Medicine, Hangzhou, Zhejiang, China. Electronic address:
Biosci Biotechnol Biochem
January 2025
Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto, 606-8502, Japan.
Protein kinase C (PKC) is a family of serine/threonine kinases, and PKC ligands have the potential to be therapeutic seeds for cancer, Alzheimer's disease, and human immunodeficiency virus infection. However, in addition to desired therapeutic effects, most PKC ligands also exhibit undesirable pro-inflammatory effects. The discovery of new scaffolds for PKC ligands is important for developing less inflammatory PKC ligands, such as bryostatins.
View Article and Find Full Text PDFClin Chim Acta
January 2025
Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China. Electronic address:
Invasive pulmonary aspergillosis (IPA), the most common fungal infection, is associated with high mortality of affected patients. Traditional diagnostic methods exhibit limited sensitivity and specificity, raising big challenges for precise management of the patients. There is thus an urgent need to find out a timely and accurate diagnostic method in clinical practice.
View Article and Find Full Text PDFJ Biomech
January 2025
Department of Orthopedic Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University Chengdu Sichuan Province China. Electronic address:
OpenCap, a smartphone-based markerless system, offers a cost-effective alternative to traditional marker-based systems for gait analysis. However, its kinematic measurement accuracy must be evaluated before widespread use in clinical practice. This study aimed to evaluate OpenCap for lower-limb joint angle measurements during walking in patients with knee osteoarthritis (OA) and to compare error metrics between patients and healthy controls.
View Article and Find Full Text PDFChild Abuse Negl
January 2025
Center for Clinical Big Data and Statistics of the Second Affiliated Hospital Zhejiang University School of Medicine, School of Public Health Zhejiang University School of Medicine, Hangzhou China. Electronic address:
Background: Nurses demonstrate a greater vulnerability to developing depressive and anxiety symptoms compared to the general population. Adverse Childhood Experiences (ACEs) are known risk factors for mental health issues, but impact of timing of these experiences remains unclear.
Objective: To investigate associations between timing of ACEs and depressive, anxiety, comorbid symptoms.
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