During a survey for other parasitic infections, tongue and limb muscles of wild bobcats (Lynx rufus) were examined microscopically from a sample of 190 Minnesota bobcats. One batch (n = 50) was studied in 2015, yielding no cases of Trichinella when examined only with hematoxylin and eosin (HE) staining of <25 mg of tissue. In a 2024 cohort (n = 140), this method was paired with a compression of ∼5 g of tissue. Although these methods were not perfectly suited to the detection of Trichinella, such larvae were nonetheless identified in one specimen. Genetic data confirmed these as Trichinella murrelli, representing the first identification of this species from any host from Minnesota.
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http://dx.doi.org/10.1016/j.vprsr.2024.101188 | DOI Listing |
Vet Parasitol Reg Stud Reports
January 2025
Minnesota Department of Natural Resources, Wildlife Health Program, 5463 West Broadway, Forest Lake, MN 55025, USA.
During a survey for other parasitic infections, tongue and limb muscles of wild bobcats (Lynx rufus) were examined microscopically from a sample of 190 Minnesota bobcats. One batch (n = 50) was studied in 2015, yielding no cases of Trichinella when examined only with hematoxylin and eosin (HE) staining of <25 mg of tissue. In a 2024 cohort (n = 140), this method was paired with a compression of ∼5 g of tissue.
View Article and Find Full Text PDFPurpose: The 18-gene MyProstateScore 2.0 (MPS2) test was previously validated for detection of Grade Group≥2 (GG≥2) prostate cancer using post-digital rectal examination (DRE) urine. To improve ease of testing, we validated MPS2 using first-catch, non-DRE urine.
View Article and Find Full Text PDFJ Anat
January 2025
Instituto de Ecorregiones Andinas (INECOA), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Universidad Nacional de Jujuy, Jujuy, Argentina.
Anatomical knowledge is fundamental for all species. In particular, myology allows a deeper understanding of ecomorphology-especially for those species hard to observe in the wild-and may be an important source for phylogenetic information. In this study, we analyzed the myological variation of the musculature of the shoulder and arm of the forelimb in species of the suborder Feliformia and its relationship with the phylogenetic history and the locomotor behavior, habitat, and predatory habits of the species within this group, using Leopardus geoffroyi as a case study.
View Article and Find Full Text PDFJ Immunother Cancer
January 2025
Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
Purpose: BMS-986299 is a first-in-class, NOD-, LRR-, and pyrin-domain containing-3 (NLRP3) inflammasome agonist enhancing adaptive immune and T-cell memory responses.
Materials And Methods: This was a phase-I (NCT03444753) study that assessed the safety and tolerability of intra-tumoral BMS-986299 monotherapy (part 1A) and in combination (part 1B) with nivolumab, and ipilimumab in advanced solid tumors. Reported here are single-center results.
Conserv Biol
January 2025
Chair of Wildlife Ecology and Management, Albert Ludwigs University of Freiburg, Freiburg, Germany.
Survival and cause-specific mortality rates are vital for evidence-based population forecasting and conservation, particularly for large carnivores, whose populations are often vulnerable to human-caused mortalities. It is therefore important to know the relationship between anthropogenic and natural mortality causes to evaluate whether they are additive or compensatory. Further, the relation between survival and environmental covariates could reveal whether specific landscape characteristics influence demographic performance.
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