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Serum sickness-like reactions clinical characteristics and management: A systematic review.
J Allergy Clin Immunol Pract
March 2025
Faculty of Medicine, McGill University, Montreal, QC, Canada.
Background: Serum sickness-like reaction (SSLR) is an adverse reaction mainly to drugs/infectious agents/ vaccines, characterized by the presence of rash, arthralgia/arthritis and occasionally fever.
Objective: This systematic review aimed to analyze the clinical characteristics, implicated agents, symptomatology, and management of SSLR.
Methods: A systematic review was conducted following PRISMA guidelines.
Serum sickness-like reactions in children - is lifelong avoidance indicated?
J Allergy Clin Immunol Pract
February 2025
Division of Pediatric Allergy Clinical Immunology and Dermatology, Department of Pediatrics, Montreal Children's Hospital, McGill University Health Center, Montreal, Quebec, Canada.
Serum sickness-like reactions (SSLR) consist of urticaria or urticarial-like rashes with joint pain and variable features of fever, angioedema and gastrointestinal distress. Allergists typically evaluate patients in the clinic for an implicated medication, such as antibiotic or vaccine. Although SSLR may be mistaken for classical serum sickness or anaphylaxis due to overlapping clinical features, there is minimal evidence for type I or type III hypersensitivity reactions.
View Article and Find Full Text PDFDupilumab-induced serum sickness-like reaction in a pediatric patient.
JAAD Case Rep
February 2025
Piedmont Plastic Surgery and Dermatology, Charlotte, North Carolina.
Serum sickness-like reactions in children taking antibiotics represent a distressing form of infection-associated urticaria and may recur unpredictably in susceptible children.
J Allergy Clin Immunol Pract
January 2025
Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Bruising, hives, and joint pain in a 3-year-old boy.
JAAD Case Rep
January 2025
Department of Dermatology, Medical College of Georgia at Augusta University, Augusta, Georgia.
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